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Solid ultrasonic coupling agent and preparation method thereof

An ultrasonic couplant and couplant technology, applied in echo/ultrasonic imaging agent and other directions, can solve the problems of complicated design and use of focused ultrasound device, electrical safety hazards and inconvenience of focused ultrasound transmitting device, and achieve convenient storage and use. And economical, good ultrasonic conduction effect, smooth surface effect

Active Publication Date: 2015-01-14
百仕联创新医学技术(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This operation is more inconvenient
No matter during use or during storage and transportation, if the air redissolves in the liquid couplant, it will lead to a decrease in its acoustic conductivity
This requires the liquid ultrasonic couplant to be kept under airtight conditions at all times, which complicates its transportation, storage and use and reduces its economy
At the same time, the possible corrosion of the transducer due to liquid contact and the potential hazard of liquid leakage to the electrical safety of the focused ultrasound emitting device will complicate the design and use of the focused ultrasound device, resulting in increased economic costs and convenience. decline of sex

Method used

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Embodiment 1

[0056] The deacetylation degree is 89%, the viscosity is 700mPa·s, and the flaky food-grade chitosan is dissolved in 4% acetic acid aqueous solution to obtain 6% chitosan acetic acid aqueous solution. The temperature of the whole dissolution process is controlled at about 40°C. The aqueous solution of chitosan acetic acid was placed under vacuum conditions at a temperature of 40° C. and -0.09 Mpa for 36 hours to fully defoam. Then, the degassed chitosan acetic acid aqueous solution is poured into the forming mold. Fully immerse the poured molding mold in the curing solution for 36 hours. The solidification solution is a 2% sodium hydroxide solution, which is added with ethanol of 1 / 10 volume of the sodium hydroxide solution, and the temperature is about 10 °C. Pour out the cured coupling agent from the mold, soak it in clean water, and change the water once every 2 hours of soaking. Obtain chitosan solid coupling agent. The chitosan solid-state coupling agent is flexible a...

Embodiment 2

[0058] The degree of deacetylation is 86%, the viscosity is 820mPa·s, and the powdery food-grade chitosan with a particle size of 80 meshes is used as the raw material and dissolved in a 2.5% acetic acid aqueous solution to obtain a 4% chitosan acetic acid aqueous solution. The temperature of the whole dissolution process is controlled at about 20°C. The chitosan acetic acid aqueous solution was placed under vacuum conditions at a temperature of 25° C. and -0.09 Mpa for 36 hours to fully deaerate. Then, the degassed chitosan acetic acid aqueous solution is poured into the forming mold. Fully immerse the poured molding mold in the curing solution for 12 hours. The solidification solution is a 6% sodium hydroxide solution, which is added with ethanol of 1 / 20 the volume of the sodium hydroxide solution, and the temperature is about 25 °C. Pour out the cured coupling agent from the mold, soak it in clean water, and change the water once every 2 hours of soaking. Obtain chitosan...

Embodiment 3

[0060] The degree of deacetylation is 82%, the viscosity is 960mPa·s, and the powdery food-grade chitosan with a particle size of 120 meshes is used as the raw material to dissolve in a 1% acetic acid aqueous solution to obtain a 2% chitosan acetic acid aqueous solution. The temperature of the whole dissolution process is controlled at about 10°C. The aqueous solution of chitosan acetic acid was placed under vacuum conditions at a temperature of 10° C. and -0.09 Mpa for 36 hours to fully defoam. Then, the degassed chitosan acetic acid aqueous solution is poured into the forming mold. Fully immerse the poured molding mold in the curing solution for 24 hours. The solidification solution is a 10% sodium hydroxide solution, which is added with ethanol of 1 / 30 of the volume of the sodium hydroxide solution, and the temperature is about 40 °C. Pour out the cured coupling agent from the mold, soak it in clean water, and change the water once every 2 hours of soaking. Obtain chitos...

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Abstract

The invention relates to a solid ultrasonic coupling agent and a preparation method thereof. The solid ultrasonic coupling agent has a shape matched with the shape of an ultrasonic transducer of a focused ultrasound launch device, and is prepared from chitosan with the degree of deacetylation of greater than 80% and the viscosity of greater than 700mPa.s as a main raw material. The solid ultrasonic coupling agent is flexible and elastic and smooth in surface, the sound transmission performance is near to that of water, and the ultrasound transmission effect is good. In addition, the solid ultrasonic coupling agent is solid, so that the solid ultrasonic coupling agent is convenient and economic to transport, store and use.

Description

technical field [0001] The invention relates to a solid ultrasonic coupling agent and a preparation method thereof, in particular to a chitosan solid ultrasonic coupling agent and a preparation method thereof. Background technique [0002] Focused ultrasound therapy has become a relatively mature medical technology. Since ultrasound cannot propagate in air, current focused ultrasound transmitters all use liquid ultrasound couplant as a conducting medium. The most common liquid ultrasonic couplant is degassed water. Use a refillable container in front of the transducer of the focused ultrasound transmitter. During focused ultrasound therapy, liquid ultrasound couplant is first poured into the container as a medium for conducting ultrasound from the transducer to the human tissue. [0003] In the process of filling the container with perfusion liquid, it is necessary to completely remove air bubbles to avoid air bubbles interfering with ultrasound conduction. This operatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22
Inventor 梁晓云
Owner 百仕联创新医学技术(北京)有限公司
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