Application of reduced coenzyme II

A reduced and coenzyme technology, applied in the biological field, can solve problems such as slow onset of action

Inactive Publication Date: 2015-01-28
SUZHOU RENBEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing anti-fatigue drugs are mainly traditional Chinese medicines, which are characterized by health preservation. Consumers need to take them for a long time, and the effect is slow

Method used

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  • Application of reduced coenzyme II
  • Application of reduced coenzyme II
  • Application of reduced coenzyme II

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1 Materials and methods

[0032] 1.1 Sample:

[0033] 1.2 Experimental animals: five-month-old middle-aged male ICR mice; eight-month-old old male C57 mice.

[0034] 1.3 Instruments and reagents: swimming box, lead wire, full-wavelength microplate reader, constant temperature water bath, centrifuge, liver glycogen detection kit (Nanjing Jiancheng, product number A043), lactic acid detection kit (Nanjing Jiancheng, product number A019-1) , Urea nitrogen kit (Nanjing Jiancheng, article number C013-1), SOD detection kit (Nanjing Jiancheng, article number A001-1), MDA detection kit (Nanjing Jiancheng, article number A003-1).

[0035] 1.4 Experimental method:

[0036] A. The first batch: 60 male five-month-old middle-aged ICR mice were randomly divided into 4 groups, 15 in each group. The low-dose group received 2.5 mg / kg intraperitoneal injection, the middle-dose 5 mg / kg intraperitoneal injection, and the high-dose 10 mg / kg intraperitoneal injection. The control group was...

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Abstract

The invention relates to the biotechnology field and in particular relates to application of a reduced coenzyme II. Test results show that NADPH can be used for obviously prolonging weight-bearing swimming time of a mouse, increasing reserve of hepatic glycogen of a fatigued mouse and reducing lactic acid and urea nitrogen content of the fatigue mouse, so that the reduced coenzyme II has an obvious anti-fatigue effect.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the use of reduced coenzyme II. Background technique [0002] Fatigue is a subjective sense of discomfort, mainly manifested as fatigue and burnout, which can be noticed during long-term labor, strenuous exercise or long-term mental stress. This is a normal physiological protective response, suggesting that the body should Rest to restore function and avoid further damage to the body. However, with the intensification of social competition and the acceleration of the pace of life, people often choose to work long hours regardless of fatigue. Being in a state of fatigue for a long time will damage the physical strength and fitness of the human body, and the body will be out of balance, making it difficult for people to engage in or complete some jobs that consume a lot of energy or have delicate and delicate movements, thereby reducing work efficiency; It makes people's skin loose a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7076A61P39/00A23L1/29A23L33/00
CPCA61K31/7076A23V2002/00A23V2200/30
Inventor 秦正红孙玮陈曹鑫寇建群
Owner SUZHOU RENBEN PHARMA
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