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Opening type micro-fluidic chip, as well as manufacture method and operation method of micro-fluidic chip

A microfluidic chip and manufacturing method technology, applied in the field of microfluidics, can solve the problems of high manufacturing cost, difficult operation, difficult large area, patterned super-smooth surface preparation, etc., to reduce the difficulty and cost of preparation, and not easy to damage Failure, the effect of reducing viscous resistance

Active Publication Date: 2015-01-28
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the published patents and articles, it is only mentioned as a smooth, non-staining, self-healing surface, and there is no mention of microfluidic manipulation of fluids or droplets for movement, nor does it mention detailed SLIPS Preparation Process
[0007] The existing SLIPS preparation process is relatively complicated, and the operation is difficult. It is difficult to prepare a large-area, patterned super-slip surface, and it is difficult to achieve complex manipulation of fluids or droplets.
In addition, the production cost is correspondingly higher

Method used

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  • Opening type micro-fluidic chip, as well as manufacture method and operation method of micro-fluidic chip
  • Opening type micro-fluidic chip, as well as manufacture method and operation method of micro-fluidic chip
  • Opening type micro-fluidic chip, as well as manufacture method and operation method of micro-fluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] In this example, an adhesive layer is first formed by coating a viscous substance, and then a microsphere template is formed by a splashing method, and then the microsphere template is patterned and cut, and then the patterned template is softly copied and transferred using PDMS to obtain a concave microsphere. Finally, lubricating oil is filled into the concave microstructure to obtain a super-smooth surface, and a planar microfluidic chip is made.

[0070] The method for making the super-slippery surface in this embodiment specifically includes the following steps:

[0071] (a) Apply a layer of glue evenly on the substrate, and the thickness of the glue should be uniform to avoid uneven surface of the formed adhesive layer.

[0072] (b) in accordance with figure 2 In the manner shown, a large number of PS microspheres are evenly sprinkled on the surface of the adhesive layer of the substrate in step (a), the substrate is tilted and the unadhered microspheres are rem...

Embodiment 2

[0078] The difference between this embodiment and Embodiment 1 is that this embodiment forms an adhesive layer by pasting double-sided adhesive tape on the substrate, and other steps are the same as Embodiment 1.

Embodiment 3

[0080] The difference between this embodiment and Embodiment 1 is that this embodiment uses a printer to print viscous substances (glue) on the substrate to form a patterned adhesive layer; Form a single-layer microsphere template; then use PDMS to perform soft replication on the single-layer microsphere template; finally, fill the lubricating oil in the concave microstructure formed by soft replication to form a lubricating oil film, obtain a super-smooth surface, and make a planar microfluidic device. chip.

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Abstract

The invention discloses an opening type micro-fluidic chip, as well as a manufacture method and an operation method of the micro-fluidic chip. The opening type micro-fluidic chip comprises a chip substrate, wherein a super-smooth surface is formed on the chip substrate; the super-smooth surface is a liquid coating layer which is filled with a lubricant and formed by a surface with a sunk micro-structure. According to the opening type micro-fluidic chip, the super-smooth surface is adopted, the viscous resistance of exogenous substances moving on the surface of the micro-fluidic chip can be greatly reduced, and thus the driving mode of the exogenous substances, especially fluid, can be expanded, the operation flexibility can be improved, and a sensitive system can be operated and controlled.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to an open microfluidic chip and its manufacturing method and control method. Background technique [0002] At present, the mainstream and relatively mature microfluidic chips are all channel-type microfluidic chips. Due to the large viscous resistance between the fluid and the tube wall, especially in micro- or nano-scale microchannels, according to the relationship between the viscous resistance and the radius in the circular tube, the diameter of the circular tube is reduced by an order of magnitude, and the viscous resistance is at least increased by more than 4 orders of magnitude. Therefore, commonly used microfluidic chips require relatively large and complex external drive devices to provide driving force. The larger driving force also leads to higher pressure in the microchannel. Therefore, the sealing requirements for the bonding of the microfluidic chip, various e...

Claims

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Application Information

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IPC IPC(8): B01L3/00
Inventor 吴天准凌世全
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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