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Method for detecting alkylphenol compounds in ginkgo leaf raw material and preparation

A detection method and compound technology, applied in measuring devices, material separation, analysis of materials, etc., can solve problems such as lack of alkylphenol compounds

Active Publication Date: 2015-03-11
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
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  • Abstract
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Problems solved by technology

[0005] In view of the above-mentioned shortcoming of prior art, the object of the present invention is to provide a kind of detection method of alkylphenol compound in Ginkgo biloba raw material and preparation, be used to solve the lack of comprehensive analysis of Ginkgo biloba raw material, extract in the prior art. The problem of the method of the content of allergenic alkylphenol compounds (ginkgolic acids, radish acids, urushiols) in intermediates and their preparations

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  • Method for detecting alkylphenol compounds in ginkgo leaf raw material and preparation
  • Method for detecting alkylphenol compounds in ginkgo leaf raw material and preparation

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Embodiment 1

[0056] 1 Reagents and instruments

[0057] 1.1 Reagents

[0058] Ginkgo biloba raw materials and Ginkgo biloba extract intermediates were purchased from Shanghai Xingling Technology Pharmaceutical Co., Ltd.; Ginkgo biloba extract preparations from Guangxi Jinsangzi Pharmaceutical Co., Ltd. Pharmaceutical Ginkgo Leaf Extract Preparation, Zhuzhou Jintai Pharmaceutical Ginkgo Leaf Extract Preparation, Haikou Qili Pharmaceutical Ginkgo Leaf Extract Preparation, Guangxi Yikang Pharmaceutical Ginkgo Leaf Extract Preparation, Guilin Xingda Pharmaceutical Ginkgo Leaf Extract Preparation, Hunan The apricot leaf extract preparations of Lishan Natural Plant Pharmaceuticals and the ginkgo leaf extract preparations of Hunan Huana Pharmaceutical Factory were purchased from the market by the Pharmacokinetics Laboratory of Shanghai Institute of Materia Medica; Ginkgo acid C13:0, Ginkgo acid C15:1, Ginkgo Acid C17:1 standard substance (purity ≥ 98%, China Institute for Food and Drug Control);...

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Abstract

The invention provides a method for detecting alkylphenol compounds in a ginkgo leaf raw material and a preparation. The method comprises the following steps: using HPLC (High Performance Liquid Chromatography) separation and ESI-Q-TOF-MS (Electric Spray Ion Source-High Resolution Quadrupole Time of Flight- Mass Spectrometry) to simultaneously determine content of alkylphenol compounds in the ginkgo leaves. The method for detecting the alkylphenol compounds in the ginkgo leaf raw material and the preparation disclosed by the invention can simultaneously detect 31 sensitized alkylphenol compounds in the ginkgo leaves, the ginkgo leaf extract and the ginkgo preparation, which comprise 22 ginkgo acid compounds, 3 resorcylic acid compounds and 6 urushiol compounds; compared with the existing alkylphenol compound analytic method at present, the method is higher in analytical ability, and capable of effectively increasing the quality control level of the processed semi-finished products and finished products of the ginkgo leaf raw material and the preparation, so as to achieve positive meaning for ensuring the clinical medication safety.

Description

technical field [0001] The invention belongs to the technical field of analysis of medicinal components, and in particular relates to a method for detecting alkylphenol compounds in ginkgo biloba raw materials and preparations. Background technique [0002] Ginkgo biloba, as the leaves of the ginkgo tree, has high medicinal value. It has obvious effects on improving brain dysfunction, arteriosclerosis, high blood pressure, dizziness, tinnitus, headache, senile dementia, memory loss, etc. Its disease prevention and treatment The value of body building and fitness has been recorded in the "Compendium of Materia Medica" by Li Shizhen in Ming Dynasty, and it is the most ideal drug ingredient for treating and preventing cardiovascular and cerebrovascular diseases recognized in the world. [0003] Ginkgo biloba extract is used to make preparations in traditional Chinese medicine. As a clinically used drug, it is effective in preventing and treating ischemic cardiovascular and cere...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
Inventor 李川牛巍钟晨春吴佩颖高崎
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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