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Compound preparation for treating acne, psoriasis and acne rosacea

A compound preparation and compound technology, applied in the field of preparations containing these three drugs, can solve the problems of skin irritation and increased skin irritation, and achieve the effects of wide indications, wide indications and good curative effect.

Active Publication Date: 2015-03-25
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no effective pharmaceutical preparation that is effective for these three dermatological diseases at the same time.
[0008] In addition, some dermatological drugs are irritating to the skin. For example, the instructions of the marketed sulfur ointment indicate that the combination of this preparation and retinoic acid will increase skin irritation.

Method used

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  • Compound preparation for treating acne, psoriasis and acne rosacea
  • Compound preparation for treating acne, psoriasis and acne rosacea
  • Compound preparation for treating acne, psoriasis and acne rosacea

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-9

[0046] Embodiment 1-9: respectively 9 kinds of compound preparations containing three kinds of medicines of the present invention;

Embodiment 1

[0050] Example 1 Tretinoin + metronidazole + sublimation sulfur compound ointment

[0051] Prescription: Tretinoin 0.1g, metronidazole 2g, sublimated sulfur 20g, liquid paraffin 50g, vitamin E 2g, Vaseline added to 1000g.

[0052]Preparation method: add tretinoin, metronidazole and sublimed sulfur into liquid paraffin, and mix uniformly to obtain a drug mixture. The vaseline is heated and melted to obtain an ointment base, the drug mixture is added into the ointment base under stirring, vitamin E is added, and the compound ointment is obtained after cooling.

Embodiment 2

[0053] Example 2 Tretinoin + metronidazole + sublimation sulfur compound cream

[0054] Recipe: tretinoin 1g, metronidazole 20g, sublimated sulfur 10g, stearyl alcohol 20g, glycerin 100g, propylene glycol 100g, monoglyceride 30g, ethylparaben 1g, ethanol 10g, distilled water to 1000g.

[0055] Preparation method: dissolve tretinoin and metronidazole with ethanol, grind sublimated sulfur into powder and pass through a 120-mesh sieve, and use the three main ingredients for later use; take stearyl alcohol and monoglyceride, heat them on a water bath to 80°C, and obtain the oil phase; Separately take propylene glycol, glycerin, and ethylparaben, add distilled water, and heat in a water bath to 80°C to obtain an aqueous phase. Slowly add the oil phase into the water phase, and stir while adding until it condenses to obtain a matrix. In the process of forming the matrix, stirring and adding three main ingredients, tretinoin, metronidazole and sublimation sulfur, obtains the compoun...

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Abstract

The invention firstly discovers compound of three active ingredients, namely tretinoin, metronidazole and sublimed sulfur has a definite effect for treating acne, psoriasis and acne rosacea. Massive scientifically designed experiments prove that compared with 'combined use of three single medicinal materials' and 'compound of two medicinal materials and a single medicinal material', the compound preparation of tretinoin, metronidazole and sublimed sulfur has an effect of improving acne like syndromes remarkably better than that of the four combined groups; in an influencing test of mouse tail scale granular layer formation for simulating psoriasis, improvement of the compound preparation for the formation rate of a mouse tail scale granular layer is remarkably better than that of the four combined groups; and in an experiment of evaluating the treatment effect on acne rosacea by an in-vitro acaricidal test, the mite death rate of the compound preparation is remarkably higher than the four combined groups. Furthermore, skin irritation contrast experiments indicate that compared with combined use of three single medicinal materials, the compound containing the three medicinal materials has smaller skin irritation.

Description

technical field [0001] The invention relates to a compatible compound of tretinoin, metronidazole and sublimated sulfur and its application in treating three skin diseases of acne, psoriasis and rosacea, and also relates to a preparation containing the three medicines. Background technique [0002] Retinoic acid is a commonly used topical drug for skin diseases, and metronidazole and sublimed sulfur have also been used in the treatment of skin diseases. Among these three drugs, there have been reports on the treatment of skin diseases with one or two of them, such as: [0003] CN201110372832.2 discloses a compound preparation, including metronidazole, chloramphenicol, borneol, sublimed sulfur, auxiliary materials include stearic acid, glycerol monostearate, lecithin, propylene glycol, triethanolamine, Tween, etc., can be Treat facial acne. [0004] CN201010108411.4 discloses a compound preparation, including 0.01%-2.5% retinoic acid drugs, 0.2%-10% antibacterial drugs and ...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61P17/06A61P17/00A61P17/10A61K31/07A61K31/4164
CPCA61K9/06A61K9/10A61K9/7015A61K31/07A61K31/4164A61K33/04A61K2300/00
Inventor 龙际淮肖丽王馨饶中树刘青春
Owner CHONGQING HUAPONT PHARMA
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