Method for manufacturing device used for detecting tumor cells
A technology of tumor cells and liquid storage pools, which is applied in the field of device preparation, can solve the problems that the detection sensitivity needs to be improved, and achieve the effects of accurate detection, improved efficiency, and improved sensitivity
Inactive Publication Date: 2015-04-01
常熟市创新模具有限公司
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Problems solved by technology
However, the existing detection sensitivity based on this method still needs to be improved. According to reports, only five or six layers of breast cancer patients have detected tumor cells by this method.
Method used
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Embodiment 1
[0025] attached figure 1 It is a schematic structural diagram of the device for detecting tumor cells, which consists of a glass substrate 1 and a silicon cover 2 sealed above the glass substrate.
[0026] attached figure 2 It is a schematic diagram of the structure of the silicon cover plate. The silicon cover plate is provided with a fluid inlet 21 and an outlet 22 , and is also provided with a raised rough area 23 of a yurt.
[0027] attached image 3 It is a structural schematic diagram of a glass substrate, and a liquid storage pool 11 is provided, and the fluid outlet and the inlet are respectively connected to the liquid storage pool through fluid channels 12 and 13 . Fluid channels include smooth channels and herringbone channels. The fluid flowing into the herringbone channel can be well mixed and even.
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Abstract
The invention belongs to the field of medical instruments, and discloses a method for manufacturing a device used for detecting tumor cells. The method comprises the following steps: a liquid storage tank and two flow channels are formed on a glass plate with an ultrasonic wave etching method, and the glass plate serves as a glass substrate; a yurt-shaped bulge coarse area is prepared on a silicon cover plate with a reaction ion etching method; two holes are prepared in the silicon cover plate with a laser punching method, the silicon cover plate is washed clean with ethyl alcohol and deionized water, and the silicon cover plate with the coarse area is prepared; the silicon cover plate is connected with the upper side of the glass substrate in a sealed mode, and the liquid storage tank corresponds to the yurt-shaped coarse area; one end of each flow channel is communicated with the liquid storage tank, and the other end of each flow channel corresponds to one of the holes. A nanometer coarse area is applied to the device used for detecting the tumor cells, the tumor cell capture efficiency is obviously improved, the detection sensitivity of the tumor cells is greatly improved and the device contributes to accurate detection of diseases.
Description
technical field [0001] The invention relates to a preparation method of a device for detecting tumor cells, and belongs to the field of medical equipment. Background technique [0002] At present, tumors are increasingly threatening human life and health. According to reports, there are about 3.12 million new cancer cases in my country every year, among which, an average of 8,550 people are diagnosed with cancer every day, and 6 people are diagnosed with cancer every minute. The national cancer mortality rate is 1.8054 / 100,000. 2.7 million cases. Such eye-catching data has attracted the attention of relevant departments, and every medical worker is also working hard to reduce tumor diseases. In addition to the incidence rate, the reason for the high mortality rate of tumors is that the malignant metastasis of tumors is the root cause of cancer recurrence and low cure rate, and the lack of effective detection of tumor cells is an important reason. [0003] Detecting tumor c...
Claims
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CPCG01N33/574
Inventor 张伟
Owner 常熟市创新模具有限公司