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Feed for inducing high-level expression of reactive protein C of animal and application thereof

A high-level expression and reactive protein technology, which is applied in the field of experimental animal models that induce high expression of special inflammatory factors, can solve the problems of rhesus monkeys such as expensive, difficult to operate, and large dosage, and achieve good application prospects and combination ratios Suitable and low cost of raw materials

Inactive Publication Date: 2015-04-08
GUANGDONG INST OF APPLIED BIOLOGICAL RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in practical applications, rhesus monkeys are more expensive, larger in size, more violent in character, difficult to operate during the experiment, and the amount of drug used in the experiment is relatively large. Many current research works are increasingly inclined to use body size Smaller, relatively mild-mannered cynomolgus monkeys as animal models of disease

Method used

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  • Feed for inducing high-level expression of reactive protein C of animal and application thereof
  • Feed for inducing high-level expression of reactive protein C of animal and application thereof
  • Feed for inducing high-level expression of reactive protein C of animal and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Using the feed prepared by the present invention to induce high-level expression of animal C-reactive protein, a non-human primate cynomolgus monkey C-reactive protein high-expression model was induced by dietary feeding.

[0019] Preparation of feed for inducing high-level expression of animal C-reactive protein:

[0020] The basic feed for the growth period of cynomolgus monkeys, based on the total mass fraction of 100%, consists of 50% corn, 16% soybean meal, 10.5% bran, 5% fish meal, 7.5% puffed soybean meal, 1% coconut oil powder, and 1.3% calcium powder. , Calcium hydrogen phosphate powder 1.5%, flour 5%, primate multivitamin 0.1%, primate polymine 0.1%, vitamin C 0.2%, lysine 1% and methionine 0.8%;

[0021] The primate multi-dimensional content per kilogram contains: Vitamin A, 15000000IU; Vitamin D3, 2.200000IU; Vitamin E, 65000IU; Vitamin K, 1000mg; Vitamin B1, 16000mg; Vitamin B2, 16000mg; Vitamin B6, 13000mg; Niacinamide, 60000mg ; D-calcium pantothenat...

Embodiment 2

[0049] This example is basically the same as Example 1, except that the formula of the feed that induces high-level expression of animal C-reactive protein is different. The total mass fraction is 100%, including: lard suet 10% and cholesterol 2%, the balance is the growth period Basic feed.

[0050] The animal experiment according to Example 1 proves that the feed for inducing high-level expression of C-reactive protein in animals of this example can effectively induce high-level expression of C-reactive protein in animals.

Embodiment 3

[0052] This example is basically the same as Example 1, except that the formula of the feed that induces high-level expression of animal C-reactive protein is different. The total mass fraction is 100%, including: lard suet 20% and cholesterol 1%, the balance is the growth period Basic feed.

[0053] The animal experiment according to Example 1 proves that the feed for inducing high-level expression of C-reactive protein in animals of this example can effectively induce high-level expression of C-reactive protein in animals.

[0054] The above research content is a further detailed description and explanation of the specific application of the present invention in combination with specific preferred embodiments, but it cannot be determined that the specific implementation of the present invention is limited to these descriptions, and can also be applied to other animals or food formulations with slight changes Or a slight change in the ratio can be used for induction in other anima...

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Abstract

The invention discloses a feed for inducing high-level expression of a reactive protein C of an animal and application thereof. The feed for inducing high-level expression of the reactive protein C of the animal comprises the following components in percentage by mass: 10-20% of leaf lard, 1-2% of cholesterol and the balance of a basal feed in growing period, totaling 100%. Researches on high expression of CRP of machin diet-induced by the feed for inducing high-level expression of the reactive protein C of the animal have related important research significance and application value. The feed further has important actual meaning on research of inflammatory diseases and mechanism research of inflammatory diseases such as atherosclerosis, cardiovascular disease and even diabetes and arthritis, research on early warning and efficacy evaluation after pharmacological intervention. The raw materials of the feed for inducing high-level expression of the reactive protein C of the animal disclosed by the invention are low in cost, wide in source, easily available and good in stability, and the feed for inducing high-level expression of the reactive protein C of the animal is simple in preparation method, easy to convey and store and has relatively good application and popularization prospects.

Description

Technical field: [0001] The invention relates to the field of experimental animal models for inducing high expression of special inflammatory factors, in particular to a feed and application for inducing high-level expression of animal C-reactive protein. Background technique: [0002] For a long time, C-reactive protein (CRP) has been regarded as a non-specific product of the acute phase reaction of inflammation, infection and tissue damage. In the past ten years, it has been found that CRP levels are associated with atherosclerosis (atherosclerosis, AS) and cardiovascular disease are closely related, which once again arouses people's strong interest in CRP. [0003] More and more evidences show that the inflammatory process plays a key role in the occurrence of AS and its complications. AS is the pathological basis of cardiovascular disease and an inflammatory autoimmune disease. The inflammatory response participates in its entire occurrence and development process. Studies ha...

Claims

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Application Information

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IPC IPC(8): A23K1/18A23K1/14A23K1/10A23K1/175A23K1/16A01K67/02
Inventor 孙云霄张礼标季芳徐强沈琪琦刘奇
Owner GUANGDONG INST OF APPLIED BIOLOGICAL RESOURCES
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