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Modified green tea polyphenols and methods thereof for treating liver disease

A technology for green tea polyphenols and liver disease, which is used in pharmaceutical formulations, antiviral agents, organic active ingredients, etc.

Inactive Publication Date: 2015-04-15
GEORGIA HEALTH SCI UNIV RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, only 10%-20% of hepatocellular carcinomas can be completely removed surgically and for those who undergo resection, recurrence rates within years of surgery are as high as 50%

Method used

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  • Modified green tea polyphenols and methods thereof for treating liver disease
  • Modified green tea polyphenols and methods thereof for treating liver disease
  • Modified green tea polyphenols and methods thereof for treating liver disease

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0168] Example 1. Fat-soluble tea polyphenols reduce precancerous liver lesions

[0169] Materials and methods

[0170] Strategy

[0171] Recently, interest in exploring chemoprevention as a method of cancer control has increased. Phytochemicals are receiving increasing attention in cancer management (Yang et al., Nat Rev Cancer, 2009, 9(6):429-439). A number of naturally occurring agents have been shown to exhibit cancer chemopreventive potential in various animal models and human diseases. Only recently has the chemopreventive effect of LTP against carcinogen-induced hepatomagenesis in vivo been investigated. To understand the role of LTP's chemopreventive activity, the present inventors employed a well-described HCC model to investigate the mechanism of action of anticancer agents by evaluating their anti-oxidative damage, anti-proliferative and anti-fibrotic effects.

[0172] Plant material and preparation.

[0173] The LTP suspension was purchased from Pulimeidi Ch...

example 2

[0215] Example 2. Antioxidative effect of lipophilic tea polyphenols

[0216] animals and diet

[0217] Pathogen-free male Sperger-Dolly rats initially weighing 140-155 g were obtained from the Experimental Animal Center of Zhejiang, China and maintained under the conventional animal facilities of the Experimental Animal Center of Zhejiang University. Animals were housed in automatically controlled conditions with a 12 hour light-dark cycle at 23°C-25°C and 50%-60% relative humidity. All rats were given standard rodent pellet chow and water ad libitum. The experimental protocol was approved by the Laboratory Animal Center and was strictly adhered to throughout the study period.

[0218] Liver carcinogenesis model

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PUM

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Abstract

Methods of treating liver disease in a subject, including administering to the subject an effective amount of one or more modified green tea polyphenols to reduce, decrease, limit or prevent one or more symptoms of liver disease relative to an untreated control subject are provided. In a preferred embodiment the one or more modified green tea polyphenols are administered at a dose of 400 mg / kg body weight five times weekly. In some embodiments the disclosed methods further include administering to the subject one or more additional pharmaceutically active agents. In one embodiment the one or more additional pharmaceutically active agents is a chemotherapeutic agent.

Description

technical field [0001] The present invention relates to the field of oncology, and in particular to the field of chemotherapy and chemoprevention. Background technique [0002] In the United States, more than 30 million people have liver disease. Chronic liver diseases, such as cirrhosis, fatty liver disease, and liver cancer, account for approximately 31,000 deaths each year in the United States. [0003] Inflammation, steatosis, and fibrosis of the liver can occur as a result of chronic alcohol abuse (alcoholic fatty liver disease), or as a result of genetic factors, lifestyle factors such as diet, infectious diseases, and exposure to environmental toxins (such as diethyl ether nitrosamines (DEN)) or food contaminated with aflatoxins. Alcoholic and nonalcoholic fatty liver disease can lead to permanent liver damage as the liver enlarges and liver cells are replaced with nonfunctional scar tissue in a process called cirrhosis (Masuoka et al Annals of the New York Academy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K45/00A61P35/00A61P1/16A61P31/14A61P31/20
CPCA61K36/82A61K45/06A61K31/00A61P1/16A61P31/14A61P31/20A61P35/00A61K2300/00
Inventor 徐德
Owner GEORGIA HEALTH SCI UNIV RES INST
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