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Cyclobenzaprine hydrochloride sustained-release capsules

A technology of cyclobenzaprine hydrochloride and sustained-release capsules, which is applied in the field of medicine, can solve problems such as unsuitability for industrial production and complicated production process, and achieve the effects of maintaining blood drug concentration, stabilizing blood drug concentration, and good patient compliance

Active Publication Date: 2015-04-22
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN103068375A relates to a tablet sleeve of cyclobenzaprine. CN102065691A mainly involves multiple coatings to form drug-containing sustained-release beads. The production process is complex and not suitable for industrial production

Method used

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  • Cyclobenzaprine hydrochloride sustained-release capsules

Examples

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Comparison scheme
Effect test

Embodiment 1-4

[0013] The preparation of embodiment 1-4 cyclobenzaprine hydrochloride sustained-release capsules

[0014] According to the raw and auxiliary materials in the following table, the cyclobenzaprine hydrochloride sustained-release capsules of four examples were prepared according to the above-mentioned preparation method. Among them, " / " means not used.

[0015] Table 1 Examples 1-4

[0016]

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PUM

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Abstract

The invention provides a method for preparing cyclobenzaprine hydrochloride sustained-release capsules and belongs to the technical field of medicines. The cyclobenzaprine hydrochloride sustained-release capsules disclosed by the invention consist of cyclobenzaprine hydrochloride, a sustained-release material, a diluent, an adhesive, a disintegrating agent and a lubricating agent, wherein the main component cyclobenzaprine hydrochloride has the effects of relieving muscle spasm and accompanying severe pain in skeletal muscles, and the sustained-release preparation can stably achieve the effects of relieving pain and spasm. The cyclobenzaprine hydrochloride sustained-release capsules are safe, effective, stable in quality, low in cost and low in administration frequency, and the patient compliance is enhanced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of cyclobenzaprine hydrochloride sustained-release capsules. The invention provides a safe and effective capsule with stable quality, low cost, less frequency of administration, enhanced patient compliance, and stable pain relief. Antispasmodic sustained-release formulation. Background technique [0002] Cyclobenzaprine hydrochloride, whose chemical name is 5-(3-dimethylaminopropene) dibenzo[a,e] cycloheptatriene hydrochloride, is a muscle relaxant developed by Merck in the United States. Muscle spasm and its accompanying severe pain in skeletal muscles have been clinically used for many years and are safe and effective. CN103068375A relates to a tablet sleeve for cyclobenzaprine. CN102065691A mainly involves multiple coatings to form drug-containing sustained-release beads. The production process is complicated and is not suitable for industrial production. ...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/135A61K47/38A61K47/36A61P21/02
Inventor 王明刚任莉陈阳生孙桂玉翟翠云刘晓霞
Owner CP PHARMA QINGDAO CO LTD
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