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Traditional Chinese medicine composite for preventing postoperative recurrence of endometriosis, and application

A technology of endometriosis and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of inability to absolutely prevent recurrence and high recurrence rate, and achieve easy quality control and less medicinal taste , the effect of saving medical resources

Active Publication Date: 2015-04-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the wide application of laparoscopy has made the treatment of endometriosis a new option, especially in foreign countries, the combination of laparoscopic surgery and "goserelin" drug has become more and more popular. Extensive treatment options, but cannot absolutely prevent recurrence, especially for stage III-IV endometriosis with a high proportion of postoperative recurrence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 Preparation of granules of the present invention

[0013] The composition of the pharmaceutical composition: 150g of danzhu leaves, 100g of red peony, 100g of curcuma, and 100g of Bupleurum.

[0014] Preparation:

[0015] (1) Add 10 times the amount of 70% ethanol to reflux extraction for 1.0 hour for the above four herbs, Danzhu leaves, Radix Paeoniae Rubra, Curcuma, and Bupleurum, extract twice in total, combine the extracts, and recover ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared by a spray dryer (controlling the spray speed to 2000ml / min, the air inlet tem...

Embodiment 2

[0017] Embodiment 2 Tablet preparation of the present invention

[0018] The composition of the pharmaceutical composition: 150g of light bamboo leaves, 100g of red peony, 100g of curcuma, and 100g of Bupleurum.

[0019] Preparation:

[0020] (1) Add 10 times the amount of 70% ethanol to reflux extraction for 1.0 hour for the above four herbs, Danzhu leaves, Radix Paeoniae Rubra, Curcuma, and Bupleurum, extract twice in total, combine the extracts, and recover ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared by a spray dryer (controlling the spray speed to 2000ml / min, the air inlet te...

Embodiment 3

[0022] Embodiment 3 Capsule preparation of the present invention

[0023] The composition of the pharmaceutical composition: 150g of light bamboo leaves, 100g of red peony, 100g of curcuma, and 100g of Bupleurum.

[0024] Preparation:

[0025] (1) Add 10 times the amount of 70% ethanol to reflux extraction for 1.0 hour for the above four herbs, Danzhu leaves, Radix Paeoniae Rubra, Curcuma, and Bupleurum, extract twice in total, combine the extracts, and recover ethanol. Concentrate under reduced pressure at 60°C until the relative density of the medicinal solution is 1.05 (measured at 30°C), and remove impurities by centrifugation at 14,000 rpm in a tubular centrifuge. The centrifuged liquid was combined with the alcohol-extracted drug solution, concentrated under reduced pressure at 60°C to a relative density of the drug solution of 1.15 (measured at 60°C). The concentrated solution is prepared by a spray dryer (controlling the spray speed to 2000ml / min, the air inlet t...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composite for preventing postoperative recurrence of endometriosis, and an application. The composite comprises the following active ingredients in parts by weight: 150-450 parts of lophatherum gracile, 100-300 parts of radix paeoniae rubra, 100-300 parts of curcuma zedoary and 100-300 parts of radix bupleuri. A preparation form of the composite is a capsule, a granule, a tablet or powder. The safety and the effectiveness of the medicine composite for preventing the postoperative recurrence of the stage III-IV endometriosis are verified via clinical research; and the composite is few in medicinal ingredient, is easily subjected to quality control and low in cost, and can be applied to prevent the postoperative recurrence of the stage III-IV endometriosis.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine composition, and relates to a traditional Chinese medicine composition for preventing postoperative recurrence of III-IV stage endometriosis, which can be used for preventing postoperative recurrence of III-IV stage endometriosis application in medicines. Background technique [0002] The incidence of endometriosis has increased significantly in recent years, and it is one of the common gynecological diseases. In gynecological laparotomy, about 5% to 15% of patients are found to have this disease; in laparoscopy for infertility, about 12% to 48% have endometriosis. Endometriosis is a common gynecological disease in women in which endometrial cells grow in abnormal positions. There are many theories about the pathogenesis of this disease, among which the theory of endometrium implantation is generally accepted. In addition, the occurrence of endometriosis is also related to the body's immune fun...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P15/00
CPCA61K9/1652A61K9/2018A61K36/233A61K36/65A61K36/71A61K36/899A61K36/9066A61K2300/00
Inventor 曲凡叶英辉吴瑞瑾周珏杨东霞翁清
Owner ZHEJIANG UNIV
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