Cancer cell/DC fusion tumor vaccine for expressing Endoglin and preparation method for cancer cell/DC fusion tumor vaccine

A technology of tumor cells and fusion cells, which is applied in the field of cancer cell/DC fusion tumor vaccines expressing tumor blood vessel marker molecules and its preparation, and can solve the problems of unsatisfactory therapeutic effects of fusion vaccines
CN104560883AActive Publication Date: 2015-04-29GUANGXI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGXI MEDICAL UNIVERSITY
Publication Date
2015-04-29

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Abstract

The invention discloses a cancer cell / DC (Dendritic Cell) fusion tumor vaccine for expressing Endoglin and a preparation method for the cancer cell / DC fusion tumor vaccine. According to the cancer cell / dendritic cell fusion tumor vaccine for expressing Endoglin and a preparation method for the cancer cell / dendritic cell fusion tumor vaccine, the method for preparing fusion cells comprises the step of fusing tumor cells and dendritic cells to obtain the fusion cells; the tumor cells are recombinant cells for expressing the Endoglin or the recombinant cells which contain the gene for encoding the Endoglin; the Endoglin is the protein of A1) or A2) below: the A1) is the protein of which the amino acid sequence is SEQ ID No.1; the A2) is the protein which has the same function as that of the protein of the A1) and is derived from the protein of the A1) performing substituting and / or deleting and / or adding on one or more amino acid residues of the amino acid sequence which is shown as the SEQ ID No.1.
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Description

technical field

[0001] The invention relates to a cancer cell / DC fusion tumor vaccine expressing tumor blood vessel marker molecules in the field of biomedicine and a preparation method thereof. Background technique

[0002] Immunotherapy for malignant tumors has become a new treatment method besides surgery, radiotherapy and chemotherapy. Among them, tumor-specific cytotoxic T lymphocyte (cytotoxic T lymphocyte, CTL) adoptive therapy has been the research focus of tumor immunotherapy. Fusion of tumor cells and dendritic cells (DC) has been widely accepted as an effective method to induce CTL. However, the therapeutic effect of fusion vaccines is still unsatisfactory, and new methods are needed to enhance the effectiveness and targeting of fusion cells to induce CTL.

[0003] Endoglin (also known as CD105, differentiation group 105) is a marker molecule of tumor blood vessels, a homodimeric transmembrane glycoprotein with a molecular weight of 180kDa, and a transforming gr...

Claims

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