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Carboxymethyl chitosan antibacterial film spray and preparation method thereof

A technology of carboxymethyl chitosan and film spraying agent, which is applied in local antibacterial agents, pharmaceutical formulas, blood diseases, etc., can solve the problems of thrombus, poor solubility, easy coagulation, etc., and achieve good biocompatibility and film formation The effect of good sex and good solubility

Inactive Publication Date: 2015-05-06
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of antibacterial spray film agents based on chitosan, but chitosan has some obvious shortcomings, such as poor solubility in water, dilute acid or pH regulator needs to be added in the preparation process, which is easy to The disadvantages of coagulation and thrombosis greatly limit its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of carboxymethyl chitosan antibacterial film spraying agent, comprises the composition of following mass volume percentage:

[0031] Carboxymethyl Chitosan 1%,

[0032] Glycerin 2%,

[0033] Deionized water balance.

[0034] The degree of deacetylation of the carboxymethyl chitosan is 90%, the degree of carboxylation is 90%, and the molecular weight is 9000.

[0035] A kind of preparation method of carboxymethyl chitosan antibacterial film spraying agent, comprises the steps:

[0036] (1) carboxymethyl chitosan is dissolved in deionized water, stirred to make it dissolve;

[0037] (2) Slowly add glycerin after the carboxymethyl chitosan is completely dissolved, and stir for 10-30 minutes until the solution is evenly mixed;

[0038] (3) Filter to remove the solid residue in the solution, and then add the remaining amount of deionized water to make it to volume.

Embodiment 2

[0040] A kind of carboxymethyl chitosan antibacterial film spraying agent, comprises the composition of following mass volume percentage:

[0041] Carboxymethyl Chitosan 2%,

[0042] Glycerin 2%,

[0043] Deionized water balance.

[0044] The degree of deacetylation of the carboxymethyl chitosan is 90%, the degree of carboxylation is 90%, and the molecular weight is 9000.

[0045] A kind of preparation method of carboxymethyl chitosan antibacterial film spraying agent, comprises the steps:

[0046] (1) carboxymethyl chitosan is dissolved in deionized water, stirred to make it dissolve;

[0047] (2) Slowly add glycerin after the carboxymethyl chitosan is completely dissolved, and stir for 10-30 minutes until the solution is evenly mixed;

[0048] (3) Filter to remove the solid residue in the solution, and then add the remaining amount of deionized water to make it to volume.

Embodiment 3

[0050] A kind of carboxymethyl chitosan antibacterial film spraying agent, comprises the composition of following mass volume percentage:

[0051] Carboxymethyl Chitosan 2%,

[0052] Glycerin 4%,

[0053] Deionized water balance.

[0054] The degree of deacetylation of the carboxymethyl chitosan is 90%, the degree of carboxylation is 90%, and the molecular weight is 9000.

[0055]A kind of preparation method of carboxymethyl chitosan antibacterial film spraying agent, comprises the steps:

[0056] (1) carboxymethyl chitosan is dissolved in deionized water, stirred to make it dissolve;

[0057] (2) Slowly add glycerin after the carboxymethyl chitosan is completely dissolved, and stir for 10-30 minutes until the solution is evenly mixed;

[0058] (3) Filter to remove the solid residue in the solution, and then add the remaining amount of deionized water to make it to volume.

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Abstract

The invention relates to a carboxymethyl chitosan antibacterial film spray and a preparation method thereof. The antibacterial film spray comprises the following components in percentage by mass-volume in final liquid: 0.5-0.4% of carboxymethyl chitosan. 0.5-10% of plasticizer, and the balance of deionized water. The preparation method comprises the following steps: dissolving the carboxymethyl chitosan, adding plasticizer, removing solid residues and performing constant volume process. The carboxymethyl chitosan antibacterial film spray not only has the characteristics of being good in film forming property, biodegradability and biocompatibility, being safe and non-toxic, and the like, but also has various pharmacological action of hemostasis, bacteriostasis, promotion of wound healing without left scars and the like. The defects that the traditional ointment, gel and other preparations are easily lost, bad in breathability, easy to pollute clothes, inconvenient to use, undesirable in effect and the like can be overcome; also, the defects that the carboxymethyl chitosan in the carboxymethyl chitosan film spray is poor in water solubility, and a diluted acid or pH regulator and the like is needed to be added can be overcome.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a carboxymethyl chitosan antibacterial film spraying agent and a preparation method thereof. Background technique [0002] Wound healing treatment is one of the common treatments in life or clinically. At present, there are many medicines and preparations for treating skin trauma clinically, mainly solutions, ointments, gels, powders, liniments, sprays, etc. However, these pharmaceutical preparations have large loss, poor water resistance, and low bioavailability. At the same time, in the process of use, some medicines need to be bandaged after medication, the air permeability is not good, and it is easy to contaminate clothes, which is inconvenient to use and poor patient compliance. In addition, most wounds will form scars after healing. Although there are many clinical methods for removing scars, such as grinding to remove scars, injection ther...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/722A61P17/02A61P31/02A61P7/04
Inventor 周建平姚静吴莹
Owner CHINA PHARM UNIV
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