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A kind of analgesic for sciatica and application thereof

A technology of sciatica and matrine, which is applied to nervous system diseases, non-central analgesics, anti-inflammatory agents, etc., can solve the problem that there is no report on the treatment of sciatica, and no literature discloses N-ethyl matrine thymol Ester analgesic activity and other issues to achieve the effect of relieving low back pain symptoms, improving mechanical pain threshold and thermal pain threshold, and obvious analgesic effect

Inactive Publication Date: 2017-10-31
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through searching the literature at home and abroad, there is currently no literature disclosing that N-ethyl matrine thymol ester has analgesic activity, especially there is no literature report on its use in the treatment of sciatica

Method used

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  • A kind of analgesic for sciatica and application thereof
  • A kind of analgesic for sciatica and application thereof
  • A kind of analgesic for sciatica and application thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0012] The following are the efficacy examples of the present invention to further explain the present invention, but the protection scope of the present invention is not limited to the following examples. The inventor designed and implemented a pharmacodynamic animal experiment to observe the effect of N-ethyl thymol matrate on an animal model of sciatica. The results showed that N-ethyl matrine thymol ester can effectively improve the pain response of nucleus pulposus-induced sciatica rats. The specific test process is as follows:

[0013] 28 male SD rats of SPF grade, weighing 250-280g. 24 of them were randomly divided into the following three groups: test drug group, positive control group, and model control group, with 8 rats in each group. The other 4 were only used to provide allogeneic nucleus pulposus. The entire experimental process was implemented and completed in strict accordance with the requirements of the International Pain Society "Outline of Pain Experimen...

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Abstract

The invention discloses an analgesic for sciatica and an application thereof. The analgesic is prepared from an active ingredient and an additive, and the active ingredient is N-ethyl matrine thymol ester, It helps relieve the symptoms of low back and leg pain caused by herniated intervertebral disc, and provides a new drug candidate for the treatment of sciatica caused by herniated lumbar intervertebral disc.

Description

technical field [0001] The invention belongs to the technical field of analgesic drugs, and in particular relates to an analgesic for sciatica and its application. Background technique [0002] Minimally invasive treatment of sciatica and low back pain caused by herniated intervertebral disc is a hotspot in clinical surgery research. Low back pain or lower extremity pain caused by lumbar disc herniation is a common disease in spine surgery. A large number of studies on its pain mechanism have shown that, in addition to mechanical compression that can cause nerve damage and then pain, the nerve roots next to the disc herniation are often accompanied by changes such as edema and inflammation. This nerve root inflammatory reaction is mainly due to the degeneration of the nucleus pulposus of the intervertebral disc. After the annulus fibrosus is ruptured, the nucleus pulposus overflows from the breach and spreads to the nerve root. The massive release of glycoprotein, substanc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61P25/02A61P29/00
Inventor 刘延莉李晓征刁其先马丕良
Owner QINGDAO MUNICIPAL HOSPITAL