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Extraction method for extractive component group of traditional Chinese medicine volatile oil treating hemorrhagic apoplexy and application of extractive component group
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A technique of hemorrhagic stroke and extraction method, applied in the field of traditional Chinese medicine, can solve the problems of insufficient curative effect and the like
Inactive Publication Date: 2015-05-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Embodiment 1
[0039] Embodiment 1: The extraction method of the volatile oil extract for the treatment of hemorrhagic stroke, the extraction steps are as follows:
[0040] (1) Raw materials: 1 part of rhubarb, 1 part of paeonol, 1 part of red peony root, 1 part of Shichangpu;
[0041] (2) Pulverize the above-mentioned crude drug to 20 mesh, add 5 times the amount of water to soak for 5 hours, extract by steam distillation for 4 hours, and collect the volatile oil extract;
[0042] (3) Analysis of volatile oil components: GC-MS was used to analyze the chemical components of volatile oil extracts. There were more than 70 volatile oil components, of which β-asarone accounted for 34.8%, paeonol 14.8%, α-asarone 5.2%, calamuscalamus Ketones 3.8%.
Embodiment 2
[0043] Embodiment 2: The extraction method of the volatile oil extract for the treatment of hemorrhagic stroke, the extraction steps are as follows:
[0044] (1) raw materials: 3 parts of rhubarb, 2 parts of paeonol, 3 parts of red peony root, 4 parts of Shichangpu;
[0045] (2) Pulverize the above-mentioned crude drug to 40 mesh, add 10 times the amount of water to soak for 10 hours, extract by steam distillation for 6 hours, and collect the volatile oil extract;
[0046] (3) Analysis of volatile oil components: GC-MS was used to analyze the chemical components of volatile oil extracts. There were more than 70 volatile oil components, of which β-asarone accounted for 30.8%, paeonol 17.8%, α-asarone 3.8%, calamus calamus Ketones 4.8%.
Embodiment 3
[0047] Embodiment 3: The extraction method of the volatile oil extract for the treatment of hemorrhagic stroke, the extraction steps are as follows:
[0048] (1) raw materials: 5 parts of rhubarb, 5 parts of paeonol, 5 parts of red peony root, 6 parts of Shichangpu;
[0049] (2) Pulverize the above-mentioned crude drug to 60 mesh, add 20 times the amount of water to soak for 12 hours, extract by steam distillation for 8 hours, and collect the volatile oil extract;
[0050] (3) Analysis of volatile oil components: GC-MS was used to analyze the chemical components of volatile oil extracts. There were more than 70 volatile oil components, of which β-asarone accounted for 36.2%, paeonol 18.2%, α-asarone 7.4%, calamus calamus Ketones 5.2%.
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Abstract
The invention discloses an extraction method for an extractive component group of traditional Chinese medicine volatile oil treating hemorrhagic apoplexy and application of the extractive component group. The extraction method comprises proportioning radix et rhizoma rhei, cortex moutan, radix paeoniae rubra and rhizoma acori tatarinowii, crushing, adding water for immersion, and extracting volatile oil by employing a water steam distillation process. Through GC-MS analysis, 70 volatile oil components are discovered, beta-asaron accounts for 30.8%-36.2%, paeonol accounts for 14.8%-18.2%, alpha-asaron accounts for 3.8%-7.4% and acorone accounts for 3.8%-5.2%. The traditional Chinese medicine volatile oil extractive is capable of substantially reducing the level of neuronspecific enolase, S-100beta protein, IL-1, TNF-alpha and plasmafibrinogen in a spontaneous hypertension male rat, and is applicable to prepare medicines treating hemorrhagic apoplexy.
Description
1. Technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an extraction method and application of a volatile oil extract component group for treating hemorrhagic stroke. 2. Background technology [0002] Hemorrhagic stroke (cerebral hemorrhage) is a common clinical disease at home and abroad. The disease has sudden onset, rapid progress, and high fatality rate. The prognosis of patients directly affects the quality of life after the disease. Neuron-specific enolase (SNE) and S-100β protein are important indicators for judging the severity of brain damage. Among them, SNE is a marker enzyme of neurons and neuroendocrine cells. When ischemia and hypoxia occur in brain tissue, Elevated levels of SNE in cerebrospinal fluid. S-100β protein is a brain-specific protein, and the higher the level of S-100β protein in serum, the more severe the brain damage. The current Western medicine treatment methods for cerebral hem...
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P9/10A61P7/04
Inventor 李国春尹莲黄西吴勉华程海波
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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