Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of stilbene glycosides in the preparation of intestinal microecological preparations

A technology of stilbene glycosides and intestines, which is applied in anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2020-06-02
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there are no literature reports on the role of stilbene glycosides as intestinal microecological preparations. Therefore, it has a good development prospect to explore whether stilbene glycosides can improve the intestinal microecological system.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of stilbene glycosides in the preparation of intestinal microecological preparations
  • Application of stilbene glycosides in the preparation of intestinal microecological preparations
  • Application of stilbene glycosides in the preparation of intestinal microecological preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Powder for Injection

[0045] Weigh 100 g of stilbene glycoside, 0.5 g of sodium metabisulfite, 9 g of sodium chloride, 40 g of mannitol, and 20 g of lactose, dissolve stilbene glycoside, sodium metabisulfite, sodium chloride, mannitol and lactose with an appropriate amount of water for injection, filter, and adjust pH to 6.7-7.4, sterilized by 0.22μm filter membrane, diluted with sterile water for injection to 1000ml, filled in 10ml brown glass bottles, 4ml per bottle, freeze-dried to obtain the finished product.

Embodiment 2

[0046] Embodiment 2 Dropping pills

[0047] Weigh 180g of stilbene glycosides, add PEG4000 2Kg as a substrate, and appropriate amount of liquid paraffin as a coolant; the liquid temperature is 50°C, the dropping speed is 12 drops per minute, the drop distance is 4.5cm, the length of the cooling column is 30cm, and the inner diameter of the drop opening is 2.5cm , coolant temperature 0°C (ice-water bath).

Embodiment 3

[0048] Example 3 Injection

[0049] Weigh 50g of stilbene glycosides, add 9g of sodium chloride, add water for injection to 1000ml, adjust the pH to 7.0-7.4, filter, fill the filtrate into ampoules of 2, 5 or 10ml, and sterilize at 100°C for 30min to obtain injection liquid.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to pharmaceutical activity study, particularly relates to an application of stilbene glycoside in preparation of an intestinal microecology preparation, and aims to provide an application of stilbene glycoside and pharmaceutically acceptable stilbene glycoside salt or stilbene glycoside ester in preparation of the intestinal microecology preparation. Stilbene glycoside can inhibit increase of a content ratio of firmicutes and bacteroidetes and improves the intestinal microecology disorder condition, thereby being expected to inhibit release of a series of inflammatory factors such as late intestinal endotoxemia and the like. Therefore, stilbene glycoside can be one good intestinal microecology preparation.

Description

technical field [0001] The present invention relates to the study of drug activity, in particular to the application of stilbene glycosides in the preparation of intestinal microecological preparations. Background technique [0002] The gut is home to microbes known as the "gut flora". If the genomics of the gut microbiota is taken as a whole, the number of genes will be more than 150 times the number of host genes. These gut flora play an important role in the nutritional and metabolic processes of the host. At present, it is believed that the gastrointestinal tract and many organisms in its lumen together form an ecological unit, which is commonly referred to as "intestinal microecology". [0003] In 1998, Marshall proposed the concept of "liver-gut axis". The important role of changes in the intestinal microbial environment in the pathogenesis of various diseases of the liver has received more and more attention. A large number of studies have confirmed that the change...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P1/00A61P29/00
Inventor 顾雯俞捷林佩闫鸿丽赵荣华毛晓健李云飞
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com