A fully human her2 antibody, its coding gene and application

A fully human, antibody technology, applied in applications, antibodies, genetic engineering, etc., can solve the problems of incomplete understanding of the resistance mechanism of Herceptin, loss of phosphorylated PTEN, abnormal signal transmission pathways, etc.
CN104650228BActive Publication Date: 2017-11-28GENOR BIOPHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GENOR BIOPHARMA
Publication Date
2017-11-28

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Abstract

The invention relates to the field of medicinal chemistry, in particular to a fully human HER2 antibody, its coding gene and application. The present invention provides a fully human HER2 antibody, wherein the amino acid sequence of the heavy chain variable region is SEQ ID NO:1, and the amino acid sequence of the light chain variable region is SEQ ID NO:2. The fully human HER2 antibody can reduce infusion reactions and immunogenicity, improve drug safety, and have better pharmacokinetic characteristics.
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Description

technical field

[0001] The invention relates to the technical field of antibodies, in particular to a fully human HER2 antibody, its coding gene and its application. Background technique

[0002] HER2 / neu (Human Epidermal Growth Factor Receptor 2, human epidermal growth factor receptor 2), also known as erbB-2, is a member of the growth factor receptor family. The receptor protein is usually only expressed in the fetal period, and it is only expressed at a low level in a few normal tissues after adulthood. However, it is expressed in a variety of human tumor tissues (such as breast cancer, gastric cancer, ovarian cancer, lung cancer, primary renal cell carcinoma). , endometrial cancer, etc.) are overexpressed, and suggest a poor prognosis. Overexpression of HER2 / neu can lead to excessive proliferation of tumor cells and formation of new blood vessels, resulting in high tumor recurrence rate, high metastasis rate and high mortality. Studies have shown that overexpression of...

Claims

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