Method for simultaneously determining vanillin, ethyl vanillin and coumarin in electronic cigarette solution

Abstract

The invention relates to a method for simultaneously determining vanillin, ethyl vanillin and coumarin in an electronic cigarette solution. The method is characterized by comprising the steps of accurately weighing a certain amount of electronic cigarette solution, carrying out vibration dilution by virtue of an organic solution containing internal standard substances, adding 1mL of solution to a 2mL chromatography bottle, and simultaneously and quantitatively analyzing the contents of vanillin, ethyl vanillin and coumarin in the cigarette solution by virtue of a gas chromatography-mass spectrum / selected ion monitoring mode (GC-MS / SIM). The method has the advantages that less sample amount and reagent amount are required, the operation is simple, rapid and efficient, the assay determination sensitivity is high, and the detection limits of vanillin, ethyl vanillin and coumarin respectively are 0.03(mu)g / mL, 0.04(mu)g / mL and 0.03(mu)g / mL, variable coefficients of determination results of vanillin, ethyl vanillin and coumarin respectively are 1.9%m 3.3% and 4.2%, the recovery rate is 96%-112%, the determination results are stable, the recovery rate is high, and the quantification is accurate.

Description

technical field [0001] The invention relates to a quantitative analysis method for vanillin, ethyl vanillin and coumarin in electronic cigarette liquid, and belongs to the field of tobacco chemistry. Background technique [0002] E-cigarette is a product that atomizes the e-cigarette solution through an atomizer to deliver nicotine and / or other substances to the respiratory system. Electronic cigarette liquid is an important part of electronic cigarettes, and electronic cigarette liquid includes synthetic liquid and natural liquid. The substances contained in the e-liquid mainly include nicotine / tobacco extract, solvents and flavors and fragrances. Among them, the use of flavors and fragrances is one of the important factors affecting the style characteristics and safety of electronic cigarette products. [0003] Coumarin, whose chemical name is 2H-1-benzopyran-2-one, is a light yellow viscous liquid. Coumarin is an aromatic compound widely present in nature, distributed i...

AI Technical Summary

Problems solved by technology

[0006] At present, some e-liquid products introduce coumarin due to the use of natural plant additives. Most e-liquid products generally use vanillin and ethyl vanillin as additives for vanilla-flavored e-liquid. There is no exact limit for the amount of additives, and these situations will bring safety hazards to e-cigarette liquid products

There is currently no literature on the quantitative analysis of coumarin, vanillin and ethyl vanillin in e-cigarette liquid

Images