Incoherent light source-based optical nipper microscope

Abstract

The invention discloses an incoherent light source-based optical nipper microscope. The microscope comprises an optical nipper microscope body and a light source which provides light to the optical nipper microscope body, wherein the light source is an LED (light-emitting diode) light source and comprises a plurality of LED chips; wave bands of the LED chips contain a plurality of wave bands with multiple types of different center wave lengths; the number of the types is equal to or smaller than the number of the LED chips; the LED chips are also arranged on a circuit layer; the circuit layer is arranged on a substrate and is also provided with a plurality of pins corresponding to the LED chips in number; the electrodes at certain ends of the LED chips are connected in series and / or in parallel; the electrodes at the opposite other ends of the LED chips are led out from the pins. Compared with the prior art, the optical nipper microscope has the advantages that the size of the optical nipper microscope is reduced, the service life of the optical nipper microscope is prolonged, more importantly, the aim that light sources with different wave lengths can be adjusted according to needs on one set of light source is also fulfilled, and the selection of the wave lengths of the optical nipper microscope is richer.

Description

technical field [0001] The invention relates to an optical tweezers microscope, in particular to an optical tweezers microscope based on an incoherent light source. Background technique [0002] Biological applications of optical tweezers microscopy include capturing viruses and bacteria, manipulating cellular structures, surface patterning, and force measurement of molecular motors and biological molecules such as DNA and proteins. Thorlabs' TOM200 Optical Tweezers Microscope System utilizes a Nikon Eclipse Ti microscope, a high-resolution XYZ piezoelectric drive stage, lasers, control and data acquisition modules, and a PC with pre-installed software to generate multiple computer-controlled optical traps. The core of the incoherent optical tweezers system is to manipulate nano- or micron-sized dielectric particles by the force generated by a highly focused laser beam. The usual way of operation is to use a Gaussian beam to focus the energy of the optical tweezers light so...

AI Technical Summary

Problems solved by technology

Using a laser as the light source of an optical tweezers microscope, compared with an incoherent light source, the laser has a large volume, a short service life, and a long switch response time; and in subsequent use, the laser light source cannot control and adjust the wavelength of the excitation light source as needed, resulting in wavelength fewer choices

Therefore, the use of lasers as excitation light sources has limited the room for improvement in volume, service life and wavelength adjustment of optical tweezers microscopes.

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