Compound montmorillonite lysozyme ointment and preparation method and application thereof

A lysozyme and montmorillonite technology, applied in the field of medicine, can solve the problems of unsatisfactory treatment effect, difficult healing of wound surface, harm of ulcer surface, etc., and achieve the effects of accelerating the formation of granulation tissue, promoting ulcer healing, and reducing the degree of edema.

Inactive Publication Date: 2015-06-10
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the raw materials, excipients, and production conditions used in the preparation are not sterilized or the sterilization method is improper, it is easy to cause secondary infection clinically, making it more difficult to heal the wound surface, and the treatment effect is very unsatisfactory or cause greater damage to the ulcer surface. harm
In addition, the montmorillonite topical medicine specially used in the treatment of skin ulcers (bedsores, scald ulcers, calf ulcers, postherpetic ulcers, diabetic ulcers, postoperative ulcers), especially the compound montmorillonite lysozyme ointment preparation has not yet been seen. to report

Method used

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  • Compound montmorillonite lysozyme ointment and preparation method and application thereof
  • Compound montmorillonite lysozyme ointment and preparation method and application thereof
  • Compound montmorillonite lysozyme ointment and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] Embodiment 1, compound montmorillonite lysozyme ointment preparation and preparation

[0173] 1. The proportion of raw and auxiliary materials (w / w):

[0174]

[0175] 2. Prepare as follows:

[0176] (1) Take by weighing each component of montmorillonite, lysozyme, polyethylene glycol 4000, glycerol, sorbitol, sterile water;

[0177] (2) Add montmorillonite to sterile water, ultrasonically disperse for 30 minutes, control the temperature at 60°C, and ultrasonic frequency at 40KHz to obtain a suspoemulsion;

[0178] (3) The suspoemulsion prepared in step (2) was sterilized by ultrasonic at 20KHz for 30min at a temperature of 150°C, then cooled to 60°C, and kept warm for later use;

[0179] (4) Weigh lysozyme according to the proportion, add sterile water to dissolve it, filter and sterilize it with a 0.22 μm filter membrane, transfer the obtained lysozyme feed liquid to a sterilized tank in the aseptic workshop, and store it at room temperature for standby;

[0180...

Embodiment 2

[0188] Embodiment 2, compound montmorillonite lysozyme ointment preparation and preparation

[0189] 1. The proportion of raw and auxiliary materials (w / w):

[0190]

[0191]

[0192] 2. Prepare as follows:

[0193] (1) Take by weighing each component of montmorillonite, lysozyme, polyethylene glycol 4000, glycerol, sorbitol, sterile water;

[0194] (2) Add montmorillonite to sterile water, ultrasonically disperse for 50 minutes, control the temperature at 38°C, and ultrasonic frequency at 30KHz to obtain a suspoemulsion;

[0195] (3) The suspoemulsion prepared in step (2) was sterilized by ultrasonic at 20KHz for 30min at a temperature of 160°C, then cooled to 60°C, and kept warm for later use;

[0196] (4) Weigh lysozyme according to the proportion, add sterile water to dissolve it, filter and sterilize it with a 0.22 μm filter membrane, transfer the obtained lysozyme feed liquid to a sterilized tank in the aseptic workshop, and store it at room temperature for stand...

Embodiment 3

[0205] Embodiment 3, compound montmorillonite lysozyme ointment preparation and preparation

[0206] 1. The proportion of raw and auxiliary materials (w / w):

[0207]

[0208] 2. Prepare as follows:

[0209] (1) Take by weighing each component of montmorillonite, lysozyme, polyethylene glycol 4000, glycerol, sorbitol, sterile water;

[0210] (2) Add montmorillonite to sterile water, ultrasonically disperse for 40 minutes, control the temperature at 50°C, and ultrasonic frequency at 35KHz to obtain a suspoemulsion;

[0211] (3) The suspoemulsion prepared in step (2) was sterilized by ultrasonication at 30KHz for 40min at a temperature of 155°C, then cooled to 65°C, and kept warm for later use;

[0212] (4) Weigh lysozyme according to the proportion, add sterile water to dissolve, filter and sterilize with a 0.22 μm filter membrane, transport the obtained lysozyme feed liquid to a sterilized tank in the aseptic workshop, and store it at room temperature for standby;

[0213] ...

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Abstract

The invention discloses compound montmorillonite lysozyme ointment for treating skin ulcers and a preparation method and application thereof. The ointment is made of, by mass, 50-120 parts of montmorillonite, 5-10 parts of lysozyme, 5-10 parts of polyethylene glycol 4000, 2-6 parts of glycerin, 3-8 parts of sorbitol and 80-164 parts of sterile water. According to the compound montmorillonite lysozyme ointment, montmorillonite and lysozyme are used as the effective constituents of the ointment and are made to the medicament with pharmaceutic adjuvant through the technologies of dissolution, high-temperature sterilization, filter membrane filtration sterilization, low-speed homogenizing, high-speed homogenizing, stirring, cooling, sterile filling and the like. The invention further provides application of the preparations for preparing medicines for treating skin ulcers. External used medicines are delivered for skin, and the ointment has good effects for treatment of skin ulcers at different times.

Description

technical field [0001] The invention relates to a compound montmorillonite lysozyme ointment for treating skin ulcers, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Skin ulcer is one of the more common clinical complications, and its formation factors are various. Refractory ulcers are often caused by long-term uncontrolled primary diseases such as burns, scalds, and diabetes. It brings great pain to patients and seriously affects their quality of life. [0003] Chronic skin ulcers, also known as refractory ulcers, are more common in the elderly, especially those with diabetes, vasculitis, and lower extremity venous reflux disorders. With the aging trend of the population and the increase in the incidence of diabetes and cardiovascular diseases, the incidence of chronic skin ulcers has also increased. Clinically, there are more and more skin ulcers caused by arteriosclerosis obliterans, diabetes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K9/06A61P17/02A61K33/06
Inventor 乔敏
Owner SHANDONG SBOND PHARMA
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