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Use of gallic acid (GA) and its pharmaceutically acceptable salt and ester

A technology of gallic acid and medicine, applied in the field of use of gallic acid and its pharmaceutically acceptable salts and esters, capable of solving problems such as unclear mechanisms

Inactive Publication Date: 2015-07-01
CHINA MEDICAL UNIVERSITY(TW)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is known that gallic acid has a variety of biological activities, including anti-oxidation, anti-inflammation, anti-tumor, reducing obesity, protecting the liver, etc., but its mechanism is still unclear

Method used

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  • Use of gallic acid (GA) and its pharmaceutically acceptable salt and ester
  • Use of gallic acid (GA) and its pharmaceutically acceptable salt and ester
  • Use of gallic acid (GA) and its pharmaceutically acceptable salt and ester

Examples

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Embodiment

[0041] Four groups (ten mice in each group) of male C57BL6 / J mice with an age of about 8 weeks and a body weight of 20-25 grams were used for experiments. The first group was the normal group (control group), and the second group was a high-fat diet The induction group, the third group were the high-dose gallic acid treatment group, and the fourth group was the low-dose gallic acid treatment group, wherein the gallic acid used was purchased from Sigma, USA.

[0042] Using the conventional feed and high-fat feed with the nutritional ratio shown in Table 1, the mice in each group were fed in the following manner. In the first group, the diet was given without restriction with the conventional feed; in the second group, the diet was given with the high-fat feed (60% of which was fatty acid) without restriction; The same high-fat feed was given without restriction, but a gallic acid aqueous solution was orally administered at a daily dose of 100 mg gallic acid / kg; in the fourth gr...

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Abstract

A method for alleviating at least one of the disturbance of bile acid metabolism, the disturbance of amino acid metabolism, and the disturbance of gut microbiota metabolism in a subject, comprising administering to the subject a composition or a health food comprising an active component selected from the group consisting of gallic acid, a pharmaceutically acceptable salt of gallic acid, a pharmaceutically acceptable ester of gallic acid, and combinations thereof.

Description

technical field [0001] The present invention relates to the application of gallic acid and its pharmaceutically acceptable salts and esters, especially the application in medical care, especially the use of gallic acid and its pharmaceutically acceptable salts and esters for manufacturing and improving bile acid metabolism disorders, amino acids Use of medicine or health food for metabolic disorder and intestinal flora metabolic disorder. Background technique [0002] Gallic acid (gallic acid, GA), also known as gallic acid or gallic acid, is a natural polyphenolic compound that widely exists in different parts of natural plants, including but not limited to the roots and stems of Rheum palmatum, Myrtle The dried leaves of Eucalyptus eucalyptus, the fruit of Cornus officinalis, the flowers of chrysanthemum, the leaves of Masang, and the peel of pomegranate, etc. Gallic acid has extremely low toxicity and good safety. Its no observed adverse effect level (NOAEL) in mice is g...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P3/00A61P1/16A61P9/12A61P3/06A61P9/10A61P39/06A61P1/04A61P25/22A61P25/24A61P37/08A61P37/02
CPCA23V2002/00A23L1/3002A61K31/192A23L33/105A61K31/216A61P1/04A61P1/16A61P3/00A61P3/06A61P9/10A61P9/12A61P25/22A61P25/24A61P37/02A61P37/08A61P39/06A61K2300/00
Inventor 彭文煌鲍力恒赵嵘郑皓元李孟修
Owner CHINA MEDICAL UNIVERSITY(TW)
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