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Application of red koji wine in preparation of medicine for preventing and/or treating metabolic syndrome

A technology of metabolic syndrome and red koji wine, which is applied in the field of medicine, can solve the problems of research reports without the influence of red koji wine on metabolic syndrome, improve the activity of antioxidant enzymes, reduce oxidative stress and inflammatory stress, The effect of suppressing the accumulation of fat

Pending Publication Date: 2022-07-01
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is no research report on the effect of red yeast rice wine on metabolic syndrome.

Method used

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  • Application of red koji wine in preparation of medicine for preventing and/or treating metabolic syndrome
  • Application of red koji wine in preparation of medicine for preventing and/or treating metabolic syndrome
  • Application of red koji wine in preparation of medicine for preventing and/or treating metabolic syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Experimental animals and feed

[0050] 84 healthy male SD rats (180-220 g) were purchased from Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd., license number: SCXK (Beijing) 2016-0006.

[0051] main reagent

[0052]

[0053]

[0054] Main instruments and equipment

[0055]

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Abstract

The invention provides application of red koji wine in preparation of a medicine for treating metabolic syndrome, and belongs to the technical field of medicines.The intake of the red koji wine can reduce the weight of rats and inhibit accumulation of fat in the body; the red koji wine reduces oxidative stress and inflammatory stress caused by HFFD by improving the activity of antioxidant enzymes and reducing the content of proinflammatory cytokines; by reducing the content of hypertensive markers (ANG-II and ET-1) caused by HFFD, the HFFD has a potential antihypertensive effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of red yeast rice wine in the preparation of medicines for preventing and / or treating metabolic syndrome. Background technique [0002] MS, also known as Syndrome X, is a collection of a series of metabolic diseases, including central obesity, IR, hyperglycemia, dyslipidemia, and hypertension, with a prevalence of 20%-45% in adults worldwide. Severe MS directly leads to the occurrence of CVD and T2DM. Obesity has become a major health problem worldwide as high fat and sugar intake continues to spread. Elevated serum FFA in obese patients can accelerate the accumulation of TG in hepatocytes and promote the occurrence of NAFLD. Hepatic steatosis leads to overproduction of hepatic ROS and an inflammatory response that negatively affects insulin signaling, ultimately leading to IR. These liver lesions greatly increase the risk of developing MS. Therefo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P3/06A61P3/10A61P3/08A61P3/00A61P1/18A61P9/12A61P29/00A61K36/062
CPCA61K36/899A61K36/062A61P3/06A61P3/10A61P3/08A61P3/00A61P1/18A61P9/12A61P29/00A61K2236/19
Inventor 周峰孔芳赖劲宇张南海周靖萱赵亮荆晓萱
Owner CHINA AGRI UNIV
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