Application of curcumin for treating myodystrophy

A technology for muscular dystrophy and curcumin, which is applied in the fields of muscular system diseases, neuromuscular system diseases, and medical preparations containing active ingredients, etc., can solve the problems of large side effects, inconclusive effects, and inconspicuous effects, and achieve a good protective effect. , Enhance the activity of antioxidant enzymes, inhibit the formation of free radicals

Inactive Publication Date: 2003-10-15
中国人民解放军南京军区联勤部军事医学研究所
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Among them, hormone therapy has a certain effect, but the side effects are too large, and the effects of other drugs are still inconclusive.
In addition, there are also some reports on the treatment of DMD with traditional Chinese medicine, such as Fuwei Decoction, and even Chinese medicine supplemented with acupuncture, but the mechanism is not clear, and the therapeutic effect is not accurate and obvious
The second is myoblast transplantation therapy, which has a certain effect in animals, but there is no successful report in humans. The main problem is that transplanted cells are difficult to survive in vivo and the treatment cost is also high.
The third is gene therapy, which is a direction that is generally favored. There have been many reports, but all clinical trials have failed, and it is impossible to form a drug to treat the human body.

Method used

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  • Application of curcumin for treating myodystrophy
  • Application of curcumin for treating myodystrophy
  • Application of curcumin for treating myodystrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] The curcumin is extracted from the crude drug turmeric with alkaline water, and then the curcumin is made into an oral agent; specifically, 10 g of the crude drug turmeric is added to 500 ml of 1% soda water, decocted to 200 ml, and the oral liquid is prepared.

[0013] Curcumin significantly reduces spontaneous muscle damage in DMD mice

[0014] Eight newborn mdx mice were randomly divided into two groups: control group and treatment group.

[0015] The control group was given intraperitoneal injection of 0.1ml PBS every other day starting from the 15th day after birth; while the treatment group was injected with 0.1ml curcumin (0.1mg) for 13 consecutive days. , organs and tissues were taken respectively, fixed in formalin, routinely embedded in paraffin for sectioning, and then histologically observed.

[0016] The results show:

[0017] 1. The protective effect of curcumin on the diaphragm of mdx mice

[0018] The mice in the control group had slight tissue damage...

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Abstract

The present invention is one medicine for treating Duchenne muscular dystrophy. Curcumin is extracted from curcuma with alkali and prepared into oral liquid for treating Duchenne muscular dystrophy. The oral liquid is superior to available medicine and method of treating Duchenne muscular dystrophy in that it has the effects of preventing muscle fiber necrosis, promoting muscle fiber regeneration, strengthening myodynamia, and lowering CPK, LDH and other biochemical indexes. Curcumin is originally used in treating tumor, ulcer, hepatitis, hyperlipemia, depression, etc.

Description

technical field [0001] The invention relates to a medicine for treating muscular dystrophy, in particular to a medicine for treating Duchenne muscular dystrophy (DMD for short in English). Background technique [0002] Before the present invention was made, there were multiple medicines and methods for the treatment of muscular dystrophy, including western medicine and traditional Chinese medicine. Muscular dystrophy diseases include Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), Limb-girdle muscular dystrophy (LGMD). Among them, DMD disease is a fatal disease caused by congenital defects and mutations of the dystrophin gene. Generally, patients will die before the age of 20. In DMD, the stability of the cell membrane is reduced, the development of myotubes is blocked, and a series of pathological changes in muscle are progressively damaged, such as the formation of large myofibrils, fat filling in connective tissue, and demyelination of nerve fibers. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P21/00
Inventor 朱敏生沈月潘英
Owner 中国人民解放军南京军区联勤部军事医学研究所
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