Production method of seratrodast
A production method and technology of cetromilast, which are applied in the field of pharmaceutical preparation, can solve the problems of low yield, complicated manufacturing process and the like, and achieve the effects of high yield, low production cost and simple manufacturing
Inactive Publication Date: 2015-07-01
张云
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Problems solved by technology
Due to the complicated manufacturing process and low yield in the production of seltroxast
Method used
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Embodiment Construction
[0006] Now in conjunction with the present invention for further detailed description.
[0007] A kind of production method of seltroxast of the present invention is characterized in that concrete steps are as follows: 2,3,5-trimethylhydroquinone (I) and 7-hydroxyphenylheptanoic acid (II) are dissolved in toluene, add D -Camphor-10-sulfonic acid, stirred at 70°C for 20h, concentrated the reaction solution, and oxidized the residue with 10% ferric chloride aqueous solution, after treatment, and then chromatographed to obtain seltroxast. Uses of seltroxast: Thrombin A2 antagonist and for the treatment of asthma.
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The invention relates to a production method of seratrodast, and is characterized in that the production method comprises the following specific steps: dissolving 2,3,5-trimethylhydroquinone (I) and 7-hydroxy benzeneheptanoic acid (II) in toluene, adding D-camphor-10-sulfonic acid, stirring for 20 h at a temperature of 70 DEG C, after a reaction liquid is concentrated, oxidizing a residue with a 10% ferric trichloride aqueous solution, after treatment, carrying out chromatography, and thus obtaining seratrodast. The production method of seratrodast is simple in manufacture, low in production cost and high in yield.
Description
technical field [0001] The invention relates to the field of medicine preparation, in particular to a production method of seltroxast. Background technique [0002] Setroxast is a thromboxane A2 receptor antagonist, which can inhibit the bronchoconstriction response caused by various chemical transmitters (thromboxane A2, leukotriene D4, platelet activating factor), and inhibit the rapid response induced by antigen inhalation. Onset and delayed hypersensitivity reactions, improved lung function. Due to the production of seltroxast, its manufacturing process is complicated and the yield is low. Contents of the invention [0003] The technical problem to be solved by the present invention is: in order to overcome the above-mentioned problems, a production method of seltroxast is provided. [0004] The technical scheme that the present invention solves its technical problem is: a kind of production method of seltroxast, it is characterized in that concrete steps are as foll...
Claims
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IPC IPC(8): C07C66/00C07C51/373A61P11/06
Inventor 张云
Owner 张云