Angiogenesis inhibition compound

An angiogenesis and compound technology, applied in the field of life sciences, which can solve the problem of less research on molecular mechanisms

Inactive Publication Date: 2015-07-01
PEKING UNIV SHENZHEN GRADUATE SCHOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, little research has been done on the molecular mechanisms that control vascular caliber and maintain the integrity of vascular endothelial cells

Method used

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  • Angiogenesis inhibition compound
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Embodiment Construction

[0007] The angiogenesis-inhibiting compound of the present invention and its applications will be further described in detail below mainly in conjunction with specific examples.

[0008] The maintenance of a fixed lumen diameter and relatively stable structure of blood vessels has an important impact on the performance of vascular functions. However, little is known about the molecular mechanisms that control and maintain vessel diameter and the integrity of vascular endothelial cells. The present invention investigates this question by chemical genetics in zebrafish embryos. A small molecule library was constructed using living Tg(kdrl:GRCFP) ZN1 transgenic embryos, in which the embryonic vascular endothelial cells were specifically labeled with green fluorescent protein. Through the analysis of the small molecule library constructed above by studying the morphology and function of embryonic blood vessels after vascular lumen formation, a new small molecule compound PP1 was ...

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Abstract

The invention relates to an angiogenesis inhibition drug. The angiogenesis inhibition drug has a structural formula shown in the following description. A result of a research on zebrafish embryonic development shows that the angiogenesis inhibition compound belongs to a Src kinase inhibitor, through VEGFR2 and MAP kinase approach inhibition, vascular endothelial cell integrity is interfered so that small blood vessel lumen diameters are gradually reduced and blood vessel endothelium is broken finally and thus the angiogenesis inhibition drug belongs to an angiogenesis inhibition compound.

Description

technical field [0001] The invention relates to the field of life sciences, in particular to an angiogenesis inhibitory compound. Background technique [0002] Biological blood vessels tend to maintain a fixed lumen diameter, and this stable structure is of great significance to the execution of vascular functions. However, little research has been done on the molecular mechanisms that control vascular caliber and maintain the integrity of vascular endothelial cells. Studying the inhibitory compounds of angiogenesis or regeneration has important guiding significance for the research of developmental biology. Contents of the invention [0003] Based on this, it is necessary to provide an angiogenesis inhibitory drug and its application. [0004] An angiogenesis inhibitory drug has the following structural formula: [0005] [0006] Through the research on the development of zebrafish embryos, the angiogenesis inhibitory compound with the above structure belongs to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04A61P35/00
CPCC07D487/04
Inventor 林硕仲寒冰
Owner PEKING UNIV SHENZHEN GRADUATE SCHOOL
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