Acetylcysteine effervescent tablet

A technology of acetylcysteine ​​and effervescent tablets, which is applied in the field of acetylcysteine ​​effervescent tablets, can solve the problems of increasing the difficulty of the process, and achieve the effects of simple preparation process, excellent effect and stable properties

Inactive Publication Date: 2015-07-08
BEIJING ZHONGYING HUIFENG SCI & TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At this time, the particle size of the acid source and the main drug acetylcysteine ​​must be 0.1-1 mm, which increases the difficulty of the process

Method used

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  • Acetylcysteine effervescent tablet
  • Acetylcysteine effervescent tablet
  • Acetylcysteine effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Prescription 20,000 tablets

[0042] Element

Dosage(kg)

Acetylcysteine ​​

12

sodium bicarbonate

4.6

aspartame

0.4

Lactose flowlac100

19.6

Leucine

2.4

[0043] crafting process:

[0044] Acetylcysteine ​​is passed through a 30-mesh sieve for later use.

[0045] Leucine is passed through a 100-mesh sieve for later use.

[0046] Acetylcysteine, sodium bicarbonate, aspartame and lactose are weighed according to the prescription amount, mixed evenly, the leucine in the prescribed amount is added, mixed evenly, put into a tablet machine, and tableted. Control hardness greater than 8kg.

[0047] The ambient temperature of tablet pressing is 20°C, the humidity is 50%, and 20,000 tablets are pressed continuously, without lagging and sticking.

Embodiment 2

[0049] Prescription 20,000 tablets

[0050] Element

Dosage(kg)

Acetylcysteine ​​

6

sodium bicarbonate

2.5

aspartame

0.4

Lactose flowlac100

27.7

Leucine

2.4

[0051] crafting process:

[0052] Acetylcysteine ​​is passed through a 30-mesh sieve for later use.

[0053] Leucine is passed through a 100-mesh sieve for later use.

[0054] Acetylcysteine, sodium bicarbonate, aspartame and lactose are weighed according to the prescription amount, mixed evenly, the leucine in the prescribed amount is added, mixed evenly, put into a tablet machine, and tableted. Control hardness greater than 8kg.

[0055] The ambient temperature of tablet pressing is 22°C, humidity is 45%, and 20,000 tablets are pressed continuously, without lagging and sticking.

Embodiment 3

[0057] Prescription 20,000 tablets

[0058] Element

Dosage(kg)

Acetylcysteine ​​

2

sodium bicarbonate

0.8

aspartame

0.4

Lactose flowlac100

19.6

Leucine

1.44

[0059] Acetylcysteine ​​is passed through a 30-mesh sieve for later use.

[0060] Leucine is passed through a 100-mesh sieve for later use.

[0061] Acetylcysteine, sodium bicarbonate, aspartame and lactose are weighed according to the prescription amount, mixed evenly, the leucine in the prescribed amount is added, mixed evenly, put into a tablet machine, and tableted. Control hardness greater than 8kg.

[0062] The ambient temperature of tablet pressing is 22°C, the humidity is 55%, and 20,000 tablets are pressed continuously, without lagging and sticking.

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Abstract

The invention discloses an acetylcysteine effervescent tablet and a preparation method thereof, and belongs to the technical field of medicines. The effervescent tablet comprises acetylcysteine, an alkali source, a sweetening agent, a filler and a lubricant. The effervescent tablet has the advantages of being less in excipient varieties, good in external properties, good in stability, simple in process, and easy in large-scale production, and the like.

Description

technical field [0001] The invention discloses an acetylcysteine ​​effervescent tablet, which belongs to the technical field of medicine. Background technique [0002] Acetylcysteine ​​is a white or off-white crystalline powder with an odor similar to garlic and a sour taste; hygroscopicity; easily soluble in water or ethanol, almost insoluble in chloroform; melting point is 104-110°C; chemistry Name: N-acetyl-L-cysteine. [0003] Chemical Structure: [0004] [0005] Molecular formula: C 5 h 9 NO 3 S [0006] Molecular weight: 163.20 [0007] Acetylcysteine ​​(acetylcysteine) is an amino acid derivative containing a sulfhydryl group (SH), and is a precursor of reduced glutathione (GSH), an important compound for cells to maintain normal physiological functions. Since the 1860s, acetylcysteine ​​has been widely used as a mucolytic agent in the expectorant treatment of respiratory diseases. It has excellent clinical efficacy in the treatment of phlegm and is well t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/46A61K31/198A61P11/00A61P1/16
Inventor 郝守祝王雷波
Owner BEIJING ZHONGYING HUIFENG SCI & TECH DEV CO LTD
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