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Medical application of notoginsenoside Ft1

A technology of notoginseng saponin and medicine, applied in the field of medical application of notoginseng saponin Ft1, which can solve the problems of reduced ability to eliminate bacteria, poor blood sugar control, poor blood circulation, etc.

Inactive Publication Date: 2015-07-08
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the blood sugar control of diabetic patients is not good, and the body's ability to eliminate bacteria will be reduced
High blood sugar can reduce the ability of cells to transport oxygen to tissues, resulting in poor blood circulation and affecting wound healing

Method used

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  • Medical application of notoginsenoside Ft1
  • Medical application of notoginsenoside Ft1
  • Medical application of notoginsenoside Ft1

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0035] 1. Experimental materials

[0036] 1.1 Medicinal materials

[0037] Notoginsenoside Ft1 (molecular weight: 917.13, HPLC purity ≥ 99%, Institute of Chinese Materia Medica)

[0038] 1.2 Experimental animals

[0039] db / db female mice (12 weeks) weighing 50±5g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SCXK (Beijing) 2011-0012. Placed in a conventional feeding environment, housed in separate cages, free to eat and drink.

[0040] 2. Experimental method

[0041] 2.1 Establishment of diabetes injury model

[0042] Using the modeling method in the literature (Nature Protocols, 2013, 8:302-309), after isoflurane anesthesia, the back skin was shaved, depilatory cream depilated, routine skin disinfection, and a hole punch with a diameter of 6 mm was used on the back spine A circular incision is made on both sides, reaching deep to the fascia. In order to prevent the wound from shrinking...

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Abstract

The invention relates to the field of medicine science, in particular to medical application of notoginsenoside Ft1. Animal experimental results prove that the notoginsenoside Ft1 can effectively promote wound healing of diabetics, so that the notoginsenoside has great significance on treating diabetic gangrene.

Description

technical field [0001] The invention relates to the field of medicine and health products, in particular to the medical use of a notoginseng saponin Ft1. Background technique [0002] Diabetes is a metabolic disease that seriously threatens human health, and has become the fourth leading cause of death after cardiovascular, tumor and AIDS. Statistics show that there are currently 285 million diabetic patients in the world, and it is predicted that by 2030, the number of diabetic patients in the world will reach 439 million, and the complications caused by diabetes have become the main cause of disability and death of patients. Among the many complications of diabetes, the impaired wound healing ability of diabetic patients is a typical complication of diabetes. If chronic injuries and ulcers occur in the feet, it may cause diabetic foot, and even lead to amputation in severe cases. Diabetes is the disease with the highest hospitalization rate, and it is reported that there ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P17/02A23L1/30A61K8/63A61Q11/00
Inventor 王峥涛张二云高波黄玲芳杨莉吴晓俊
Owner SHANGHAI UNIV OF T C M