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Application of compound notoginsenoside Ft1 in preparation of drugs for treatment of Parkinson's disease

A Parkinson's disease, notoginseng saponin technology, applied in the application field of medicine and functional food, can solve the application and report of notoginseng saponin Ft1 that has not been discovered, the patient cannot be cured, and the report of the application of the compound has not been found, etc.

Inactive Publication Date: 2018-01-26
YUNNAN AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the clinically used drugs for the treatment of PD are divided into six categories: anticholinergics, amantadine, dopamine replacement therapy, dopamine receptor agonists, monoamine oxidase-B inhibitors, and COMT inhibitors. Kimson develops symptoms, but does not cure patients
[0004] So far, the application and report of notoginseng saponin Ft1 as an active ingredient in the treatment of PD has not been found, nor has there been any report on the application of this compound in the preparation of drugs and functional foods for the treatment of PD.

Method used

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  • Application of compound notoginsenoside Ft1 in preparation of drugs for treatment of Parkinson's disease
  • Application of compound notoginsenoside Ft1 in preparation of drugs for treatment of Parkinson's disease
  • Application of compound notoginsenoside Ft1 in preparation of drugs for treatment of Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Preparation of notoginseng saponin Ft1:

[0017] The stems and leaves of notoginseng are extracted with 10 times the amount of 1% HCl solution, extracted twice, each time for 2 hours, the filtrates are combined, the pH is adjusted to 7 with 3% NaOH solution, concentrated and dried to obtain a dry paste. Dry paste 100g, mix sample with silica gel (200-300 mesh) and carry out silica gel column chromatography, use chloroform: methanol: water (8:2:0.2) as eluent, thin layer chromatography checks and merges the same color point Fractions, Fr1-5 fractions were obtained. Fr4 (5g) was subjected to repeated silica gel column chromatography and reversed-phase silica gel RP-18 column chromatography (methanol: water / 7:3) with chloroform: methanol: water (8:2:0.2) as the eluent to obtain three Heptasaponin Ft1 (0.12 g).

[0018] Structural identification of notoginseng saponin Ft1:

[0019] Instrument: mass spectrometry (MS) is measured with VGAutopec-3000 mass spectrometer; nucl...

Embodiment 2

[0026] Activity experiment of notoginseng saponin Ft1 in treating PD function:

[0027] 1. Materials

[0028] 1.1 Animal source

[0029] SPF grade C57 / BL6J mice, male, 22-24 g, 12-14 weeks, provided by Chengdu Dashuo Experimental Animal Co., Ltd. Animal production license number: SCXK (Sichuan) 2015-030. The mice were kept in the IVC animal laboratory at a temperature of 20-25°C (daily temperature difference ≤3°C); humidity 40%-70%; lighting 12h: 12h alternating light and dark, illumination 150-300lx; noise ≤60dB. Experimental animal use license: SYXK (Dian) K2013-0002, issuing unit: Kunming Science and Technology Bureau.

[0030] 1.2 Drugs and reagents

[0031] Notoginseng saponin ft1 (supplement); 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was purchased from Sigma, USA, product number M0896; TH Rabbit Polyclonal antibody was purchased from proteintech, product number : 25859-1-AP, DAB staining solution (enhanced polymer method) kit was provided by Fuzhou Maixin...

Embodiment 3

[0059] Dissolve notoginseng saponin Ft1 in sterile water for injection to dissolve, then filter through a sterile funnel, fine filter, potting, and sterilize,

[0060] Made into injection.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treatment of Parkinson's disease (PD). The pharmaceutical composition adopts compound notoginsenoside Ft1 as the effective ingredient and contains a conventional pharmaceutical carrier. At the same time, the invention provides application of the compound notoginsenoside Ft1 in preparation of drugs for treatment of PD, and application of the compound notoginsenoside Ft1 in preparation of functional food for treatment of PD.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of the active ingredient notoginsenoside Ft1 (notoginsenoside Ft1) in medicines and functional foods for treating Parkinson's disease PD. Background technique: [0002] Parkinson's disease (PD) is a kind of chronic degeneration of the central nervous system. α-Syn) deposition and the appearance of Lewy bodies (LB) are characterized. PD can damage the function of movement and language. The clinical manifestations are static tremor, muscle rigidity, slow movement and language, mental depression, and mental decline. Bedridden for a long time, the quality of life is seriously reduced. According to statistics, the prevalence of PD in the world is 0.3%, 1%-2% for people over 65 years old, 3%-5% for people over 85 years old, and the prevalence rate of men is higher than that of women, which shows the prevalence and incidence of PD With the increase of a...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P25/16A23L33/105
Inventor 沈勇祁燕何丹
Owner YUNNAN AGRICULTURAL UNIVERSITY