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Applications of compound 20(R)-notoginsenoside Ft1 and pharmaceutical composition of compound 20(R)-notoginsenoside Ft1 in preparation of anti-inflammatory drugs

A technology of notoginseng saponins and compounds, applied in the field of medicine, can solve problems such as reports that the application of compounds has not been found, and problems that have not yet been found.

Inactive Publication Date: 2017-12-15
YUNNAN AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, the application and report of 20(R)-notoginseng saponin Ft1 as an active ingredient in the anti-inflammatory function has not been found, nor has the report of the application of this compound in the preparation of anti-inflammatory drugs and functional foods been found.

Method used

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  • Applications of compound 20(R)-notoginsenoside Ft1 and pharmaceutical composition of compound 20(R)-notoginsenoside Ft1 in preparation of anti-inflammatory drugs
  • Applications of compound 20(R)-notoginsenoside Ft1 and pharmaceutical composition of compound 20(R)-notoginsenoside Ft1 in preparation of anti-inflammatory drugs
  • Applications of compound 20(R)-notoginsenoside Ft1 and pharmaceutical composition of compound 20(R)-notoginsenoside Ft1 in preparation of anti-inflammatory drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Preparation of 20(R)-notoginsenoside Ft1:

[0024] The stems and leaves of notoginseng are extracted with 10 times the amount of 1% HCl solution, extracted twice, each time for 2 hours, the filtrates are combined, the pH is adjusted to 7 with 3% NaOH solution, concentrated and dried to obtain a dry paste. Dry paste 100g, mix sample with silica gel (200-300 mesh) and carry out silica gel column chromatography, use chloroform: methanol: water (8:2:0.2) as eluent, thin layer chromatography checks and merges the same color point Fractions, Fr1-5 fractions were obtained. Fr4 (5g) is carried out repeated silica gel column chromatography with chloroform: methanol: water (8:2:0.2) as eluent, and reverse phase silica gel RP-18 column chromatography (methanol: water / 7:3), obtains 20 (R)-Notoginsenoside Ft1 (0.12 g).

[0025] Structural identification of 20(R)-notoginsenoside Ft1:

[0026] Instrument: mass spectrometry (MS) is measured with VGAutopec-3000 mass spectrometer; nuc...

Embodiment 2

[0033] In vivo anti-inflammatory activity experiment of 20(R)-notoginsenoside Ft1:

[0034] 1 drug

[0035] (1) Test drug

[0036] 20(R)-Notoginsenoside Ft1, white powder; it was ground with 0.05% sodium carboxymethyl cellulose to make a suspension during the experiment.

[0037] (2) Control drug

[0038]Indomethacin Enteric-coated Tablets, approved by the State Council H50020263, 25mg / tablet, the usual dosage for adults is 1-2 tablets each time, 2-3 times a day; produced by Chongqing Kerui Pharmaceutical Co., Ltd., batch number 259002, shading and sealed storage.

[0039] Aspirin Enteric-Coated Tablets, approved by the State Drug Administration J20130078, imported drug registration certificate number H20130192, 100mg / tablet, sealed, stored below 25°C.

[0040] (3) Dose setting and preparation method

[0041] For indomethacin enteric-coated tablets, the clinical dosage is 150mg / day / person, and the test dose is set at 10mg / kg, which is equivalent to 4 times the clinical dos...

Embodiment 3

[0072] Dissolve 20(R)-notoginsenoside Ft1 in sterile water for injection, dissolve, and then filter through a sterile funnel, fine filter, potting, and sterilize to make an injection.

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Abstract

The invention provides applications of compound 20(R)-notoginsenoside Ft1 in preparation of anti-inflammatory drugs, and a pharmaceutical composition with anti-inflammatory functions. Compound 20(R)-notoginsenoside Ft1 is taken as the effective component of the pharmaceutical composition, and the pharmaceutical composition also contains common pharmaceutical carriers. The invention also provides applications of compound 20(R)-notoginsenoside Ft1 in preparation of functional food with anti-inflammatory functions.

Description

Technical field: [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of active ingredient 20(R)-notoginsenoside Ft1 (20(R)-notoginsenoside Ft1) and its pharmaceutical composition in the preparation of anti-inflammatory medicine and functional food. Background technique: [0002] Inflammation is a common clinical pathological process that can occur in tissues and organs in various parts of the body. Acute inflammation usually has changes such as redness, swelling, heat, pain, and dysfunction, and is often accompanied by systemic reactions such as fever and leukocytosis. It is an objective reflection of the body's struggle with inflammatory factors and runs through the entire inflammatory process. After the inflammatory factors act on the body, on the one hand, it causes damage to tissue cells, causing local tissue cells to degenerate and necrosis; Repair, so that after the body is damaged, the internal environment of...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P29/00A61P19/02A23L33/11
CPCA61K31/704A23L33/11A23V2002/00A23V2200/30A23V2250/2136
Inventor 沈勇
Owner YUNNAN AGRICULTURAL UNIVERSITY