Application of notoginsenoside Ft1

A technology of Panax notoginseng saponins and uses, applied in the field of medicine, can solve the problems of not seeing Panax notoginseng saponins Ft1 and the like, and achieve the effects of improving lipid metabolism and wide application prospects

Active Publication Date: 2018-05-11
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, reports on the pharmacological activities of notoginseng saponin Ft1 are mainly hypolipidemic, anti-tumor, eliminating o

Method used

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  • Application of notoginsenoside Ft1
  • Application of notoginsenoside Ft1
  • Application of notoginsenoside Ft1

Examples

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Embodiment Construction

[0032] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. Percentages and parts are by weight unless otherwise indicated.

[0033] 1. Materials and Reagents

[0034] 1.1 Main instruments and equipment

[0035] Precision balance (Sartorius, Germany);

[0036] 1X20 automatic biochemical analyzer (Beckman, USA);

[0037] Thermometer (Physitemp Instruments, Inc., the United States);

[0038] Blood glucose meter (Johnson&Johnson, USA);

[0039] Ultrasonic Disintegrator Soniprepl50 Ultrasonic Disintegrator (MSE, UK);

[0040] Microplate reader spectrophotometer (BioTek, USA);

[0041] Clean bench (...

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Abstract

The invention discloses an application of notoginsenoside Ft1 and particularly provides the application of notoginsenoside Ft1 to preparation of a TGR5 agonist as an active ingredient. Studies prove that notoginsenoside Ft1 has a remarkable TGR5 agonist activity and can serve as an effective ingredient of the TGR5 agonist. Besides, a C57BL/6J mouse is taken as a study object, the studies prove that notoginsenoside Ft1 can effectively improve lipid metabolism, glycometabolism and insulin sensitivity of the mouse when used as the TGR5 agonist, can be applied to preparation of drugs and health food for preventing and/or treating metabolic diseases and is particularly expected to be applied to preparation of the drugs or the health food for preventing and/or treating abnormal glucose metabolism, abnormal lipid metabolism or/and abnormal insulin sensitivity.

Description

technical field [0001] The invention relates to the use of notoginseng saponin Ft1, which belongs to the technical field of medicine. Background technique [0002] With the development of society and the change of diet structure, the prevalence of obesity is rapidly increasing, and it has become a global public health problem. According to the survey data of the World Health Organization (WHO), as of 2005, the incidence of obesity in the world has accounted for 33% of the adult population, and it is estimated that by 2030, the incidence of obesity will reach 57.8%. Obesity has become a disease that endangers people's health. It is closely related to the occurrence and development of many diseases. Obesity is closely related to diabetes, especially to type 2 diabetes mellitus (T2DM). Overweight and obese people in China Diabetes prevalence rates were 12.8% and 18.5% respectively; in diabetic patients, the proportion of overweight was 41%, the proportion of obesity was 24.3%,...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P3/00A61P3/10A61P3/06A61P3/04A61P1/16A61P5/50A23L33/105
CPCA23L33/105A23V2002/00A61K31/704A23V2200/30A23V2200/3262A23V2200/326A23V2200/328A23V2200/332A23V2250/21
Inventor 杨莉王峥涛丁丽丽张二云
Owner SHANGHAI UNIV OF T C M
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