Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of notoginsenoside Ft1

A technology of Panax notoginseng saponins and uses, applied in the field of medicine, can solve the problems of not seeing Panax notoginseng saponins Ft1 and the like, and achieve the effects of improving lipid metabolism and wide application prospects

Active Publication Date: 2018-05-11
SHANGHAI UNIV OF T C M
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, reports on the pharmacological activities of notoginseng saponin Ft1 are mainly hypolipidemic, anti-tumor, eliminating oxygen free radicals, and anti-oxidative effects. So far, there have been no reports on the use of notoginseng saponin Ft1 as a TGR5 agonist

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of notoginsenoside Ft1
  • Application of notoginsenoside Ft1
  • Application of notoginsenoside Ft1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0032] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. Percentages and parts are by weight unless otherwise indicated.

[0033] 1. Materials and Reagents

[0034] 1.1 Main instruments and equipment

[0035] Precision balance (Sartorius, Germany);

[0036] 1X20 automatic biochemical analyzer (Beckman, USA);

[0037] Thermometer (Physitemp Instruments, Inc., the United States);

[0038] Blood glucose meter (Johnson&Johnson, USA);

[0039] Ultrasonic Disintegrator Soniprepl50 Ultrasonic Disintegrator (MSE, UK);

[0040] Microplate reader spectrophotometer (BioTek, USA);

[0041] Clean bench (...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of notoginsenoside Ft1 and particularly provides the application of notoginsenoside Ft1 to preparation of a TGR5 agonist as an active ingredient. Studies prove that notoginsenoside Ft1 has a remarkable TGR5 agonist activity and can serve as an effective ingredient of the TGR5 agonist. Besides, a C57BL / 6J mouse is taken as a study object, the studies prove that notoginsenoside Ft1 can effectively improve lipid metabolism, glycometabolism and insulin sensitivity of the mouse when used as the TGR5 agonist, can be applied to preparation of drugs and health food for preventing and / or treating metabolic diseases and is particularly expected to be applied to preparation of the drugs or the health food for preventing and / or treating abnormal glucose metabolism, abnormal lipid metabolism or / and abnormal insulin sensitivity.

Description

technical field [0001] The invention relates to the use of notoginseng saponin Ft1, which belongs to the technical field of medicine. Background technique [0002] With the development of society and the change of diet structure, the prevalence of obesity is rapidly increasing, and it has become a global public health problem. According to the survey data of the World Health Organization (WHO), as of 2005, the incidence of obesity in the world has accounted for 33% of the adult population, and it is estimated that by 2030, the incidence of obesity will reach 57.8%. Obesity has become a disease that endangers people's health. It is closely related to the occurrence and development of many diseases. Obesity is closely related to diabetes, especially to type 2 diabetes mellitus (T2DM). Overweight and obese people in China Diabetes prevalence rates were 12.8% and 18.5% respectively; in diabetic patients, the proportion of overweight was 41%, the proportion of obesity was 24.3%,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/704A61P3/00A61P3/10A61P3/06A61P3/04A61P1/16A61P5/50A23L33/105
CPCA23L33/105A23V2002/00A61K31/704A23V2200/30A23V2200/3262A23V2200/326A23V2200/328A23V2200/332A23V2250/21
Inventor 杨莉王峥涛丁丽丽张二云
Owner SHANGHAI UNIV OF T C M
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com