A kind of bacterial cellulose dressing with antibacterial and antibacterial function and its preparation method and application
A technology of bacterial cellulose and bacterial cellulose membrane, which is applied in the field of biomedical materials to achieve the effects of promoting wound healing, controllable degree of modification reaction and simple operation
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Embodiment 1
[0047] Prepare the bacterial cellulose dressing with antibacterial and antibacterial function with low grafting rate and low load according to the following steps:
[0048] (1) Weigh 0.4 g bacterial cellulose dry film with a thickness of about 0.2mm (about 2.46 mmol, the molecular weight of its structural unit is 162 g / mol, the same below) and add it to 100ml LiCl / DMAc solution containing 7% LiCl , stirring slowly for 1 hour at room temperature, so that the bacterial cellulose membrane has obvious uniform swelling, and the thickness reaches about 1.0mm;
[0049] (2) After raising the temperature of the bacterial cellulose system above to 50°C, add 0.6 g of maleic anhydride under stirring conditions, without adding a catalyst, and continue stirring for 2 hours;
[0050] (3) After the reaction is completed, fully wash the bacterial cellulose membrane in a sufficient amount of anhydrous methanol;
[0051] (4) Transfer the washed bacterial cellulose membrane to 50ml methanol solu...
Embodiment 2
[0056] Prepare the bacterial cellulose dressing with antibacterial and antibacterial function in the grafting rate in the following steps:
[0057] (1) Weigh 0.2 g bacterial cellulose dry film (about 1.23 mmol) with a thickness of about 0.1mm and add it to 100ml LiCl / DMAc solution containing 8% LiCl, and stir slowly for 3 hours at room temperature to make the bacterial cellulose film There is obvious uniform swelling, and the thickness reaches about 1.5mm;
[0058] (2) After raising the temperature of the bacterial cellulose system above to 65°C, add 0.85g of maleic anhydride and 0.01g of DMAP catalyst under stirring conditions, and continue stirring for 3 hours;
[0059] (3) After the reaction is completed, fully wash the bacterial cellulose membrane in a sufficient amount of absolute ethanol;
[0060] (4) Transfer the washed bacterial cellulose membrane to 50ml ethanol solution containing 0.01mol / L zinc acetate, and stir continuously at 50°C for 1.5h;
[0061] (5) Add 50ml...
Embodiment 3
[0066] Prepare the bacterial cellulose dressing with antibacterial and antibacterial function in the high grafting rate according to the following steps:
[0067] (1) Weigh 0.2 g bacterial cellulose dry film (about 1.23 mmol) with a thickness of about 0.2 mm and add it to 100 ml LiCl / DMAc solution containing 10% LiCl, and stir slowly for 3 hours at room temperature to make the bacterial cellulose film There is obvious uniform swelling, and the thickness reaches about 2.0mm;
[0068] (2) After raising the temperature of the bacterial cellulose system above to 60°C, add 1.2g of maleic anhydride and 0.015g of DMAP catalyst under stirring conditions, and continue stirring for 3 hours;
[0069] (3) After the reaction is completed, fully wash the bacterial cellulose membrane in a sufficient amount of absolute ethanol;
[0070] (4) Transfer the washed bacterial cellulose membrane to 50ml ethanol solution containing 0.02mol / L zinc acetate, and stir continuously at 50°C for 1.5h;
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