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HPMCP (hydroxypropyl methylcellulose phthalate) and preparation method

A technology of phthalate and hypromellose, which is applied in the field of hypromellose phthalate and its preparation, can solve the problems of inability to use food-grade products and high cost, and achieve low cost, Excellent viscosity and wide source of raw materials

Inactive Publication Date: 2015-09-09
DEQING WEIKANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Phthalate is a commonly used plastic plasticizer. This plasticizer is an industrial-grade chemical raw material and cannot be used in food-grade products. With the continuous development and application of pharmaceutical products, enteric-soluble The application of sugar-coated raw materials is more and more widespread, but because this food-grade enteric-coated sugar-coated material must meet the standards of human body safety, it requires relatively strict raw materials and production processes, so the cost is high and the production process is relatively complicated. Therefore, it is urgently needed An enteric-coated sugar-coated product with wide sources of raw materials, low cost, simple and reliable production process

Method used

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preparation example Construction

[0013] A method for preparing hypromellose phthalate as described above, said preparation method comprising: putting lignocellulose, solvent and sodium acetate in proportion to dissolving in a one-step reaction kettle for 1.5-2.5 hours, Then add the phthalic anhydride and the catalyst together into a one-step reaction kettle, and react at a temperature of 60-120° C. for 6-8 hours.

[0014] A preferred embodiment of the present invention is: the dissolution time is 2 hours, the reaction temperature is 90-100° C., the reaction is 7 hours, and the finished product is prepared after 2 hours of heat preservation.

Embodiment 1

[0015] Embodiment 1: a kind of hypromellose phthalate, it is mainly formed by the reaction of the following components according to the following ratio: 1 weight part of lignocellulose, 0.5 weight part of phthalic anhydride, 0.5 weight part of Sodium acetate, 0.3 part of catalyst and the solvent of 25 parts by weight; Described solvent is acetic acid;

[0016] A preparation method of hypromellose phthalate, said preparation method comprising: putting lignocellulose, solvent and sodium acetate in proportion to dissolving in a one-step reaction kettle for 2 hours, and then adding phthalic anhydride and Add the catalyst together into a one-step reaction kettle, react at a temperature of 90-100°C for 7 hours, and keep warm for 2 hours to make a finished product.

Embodiment 2

[0017] Embodiment 2: a kind of hypromellose phthalate, it is mainly formed by the reaction of the following components according to the following ratio: 1 weight part of lignocellulose, 0.4 weight part of phthalic anhydride, 0.4 weight part of Sodium acetate, 0.1 part of catalyst and the solvent of 20 parts by weight; Described solvent is acetone;

[0018] A kind of preparation method of described hypromellose phthalate, described preparation method comprises: putting lignocellulose, solvent and sodium acetate in proportion to dissolving in one-step reactor for 1.5 hours, and then dissolving Add the phthalic anhydride and the catalyst into the one-step reactor together, and react at a temperature of 60° C. for 6 hours.

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PUM

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Abstract

The invention discloses HPMCP (hydroxypropyl methylcellulose phthalate) and a preparation method. The HPMCP is mainly prepared from components in parts by weight as follows: 1 parts of lignocellulose, 0.4-0.6 parts of phthalic anhydride, 0.4-0.6 parts of sodium acetate, 0.1-0.5 parts of a catalyst and 20-30 parts of a solvent through reactions, wherein the solvent is one of acetic acid, acetone and ethanol. The preparation method comprises steps as follows: the lignocellulose, the solvent and the sodium acetate are placed in a one-step reaction kettle in proportion to be dissolved for 1.5-2.5 h, then the phthalic anhydride and the catalyst are added to the one-step reaction kettle, and the mixture reacts at the temperature of 60-120 DEG C for 6-8 h. The HPMCP and the preparation method have the characteristics that the raw material source is wide, the cost is low, the preparation process is simple and reliable, and the like.

Description

technical field [0001] The invention relates to a medicinal hypromellose phthalate and a preparation method thereof, and belongs to the technical field of pharmaceutical enteric sugar-coating materials and preparation. Background technique [0002] Phthalate is a commonly used plastic plasticizer. This plasticizer is an industrial-grade chemical raw material and cannot be used in food-grade products. With the continuous development and application of pharmaceutical products, enteric-soluble The application of sugar-coated raw materials is more and more widespread, but because this food-grade enteric-coated sugar-coated material must meet the standards of human body safety, it requires relatively strict raw materials and production processes, so the cost is high and the production process is relatively complicated. Therefore, it is urgently needed The invention provides an enteric-coated sugar-coated product with wide sources of raw materials, low cost, simple and reliable ma...

Claims

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Application Information

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IPC IPC(8): C08B13/00
Inventor 沈玉田
Owner DEQING WEIKANG BIOTECH
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