Decoquinate nanometer preparation and preparing method and application thereof

Abstract

The invention discloses a decoquinate nanometer preparation. The decoquinate nanometer preparation comprises decoquinate and an amphipathy surface active agent which is L-alpha phosphatidylcholine. The grain size of the decoquinate nanometer preparation is not larger than 300 nm. The dissolution rate of the active ingredient decoquinate is increased through introduction of the amphipathy surface active agent, the specific surface area of the decoquinate nanometer preparation with the grain size not larger than 300 nm is increased, the dissolution rate of the decoquinate is increased, and the absorption by the intestinal tract is effectively improved. In general, the dissolution rate of the decoquinate in the decoquinate nanometer preparation, the bioavailability and the malaria resisting drug effect are far higher than those of the micrometer decoquinate preparation. The invention further provides a preparing method for the decoquinate nanometer preparation. By means of introduction of the amphipathy surface active agent and an ultrasonic or high-pressure homogenate method, the micrometer decoquinate preparation is scattered into the decoquinate nanometer preparation.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a decoquinate nano-preparation and its preparation method and application. Background technique

[0002] Malaria is a disease caused by the parasite Plasmodium that is transmitted by the bite of an Anopheles mosquito. After the malaria parasite reaches the human body through mosquito bites, it first develops from sporozoites into merozoites in the liver, and then infects red blood cells. Plasmodium infects red blood cells, causing symptoms such as fever, headache, fatigue and vomiting. These symptoms usually appear 10 to 15 days after the mosquito bite. Patients usually need timely treatment, otherwise it will damage the patient's vital organs and even threaten the patient's life safety. According to statistics from the World Health Organization in 2013, nearly 3.4 billion people in 97 countries are at risk of suffering from malaria, of which 1.2 billion are at hi...

Images