A kind of total bufolide liposome injection and preparation method thereof

A technology of total bufalinide and injection, applied in the directions of liposome delivery, antiviral agents, pharmaceutical formulations, etc., can solve the problems of being easily affected by the surrounding environment, drug leakage, unstable liposome properties, etc. , to achieve the effect of prolonging local aggregation, reducing toxicity and reducing vascular irritation
CN104922072BActive Publication Date: 2018-06-19HEFEI HUAFANG PHARMA SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HEFEI HUAFANG PHARMA SCI & TECH
Publication Date
2018-06-19

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Abstract

The invention belongs to the field of medicinal preparation and particularly relates to total toad-poison lactone liposome injection and a preparing method thereof. Total toad-poison lactone liposome is basically composed of the treatment effective quantity of total toad-poison lactone, phospholipid, cholesterol, an antioxidant, PBS liquid, organic solvent and water for injection. The liposome injection has the excellent preparation stability, the situation that in the freezing process, due to fusion and ice crystals, the liposome fractures is avoided, and the liposome keeps high encapsulation efficiency as well after being stored for a long term; the solubility of total toad-poison lactone is improved, the quality and the biological availability of preparation products are improved, the total toad-poison lactone can enter the body stably at a constant speed, and can be used in clinic more safely and effectively, and the theoretic foundation is provided for clinic application of the total toad-poison lactone liposome injection.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a natural active ingredient total bufolide liposome injection and a preparation method. Background technique

[0002] Cinobufacin is extracted from the skin of the traditional Chinese medicine Bufo bufo, and it is a traditional Chinese medicine injection that is extracted by water and alcohol. Cinobufacin injection has a significant anti-tumor effect. It has been found through research that cinobufacin injection is rich in water-soluble indole alkaloids (such as 5-hydroxytryptamine, bufotryptamine, toadine, toad sulfur, etc.), amino acids and other components, and the total anti-tumor activity The content of bufolides (bufaxins, bufotoxins) is extremely low. It is clinically believed that cinobufacin local venous irritation, arrhythmia, skin reactions, and asthma are all caused by the pharmacological effects of water-soluble indole alkaloids, and there is no research r...

Claims

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