One-step method for preparing chitosan microspheres with controllable morphology
A technology of chitosan microspheres and chitosan, which is applied in the preparation of microspheres, microcapsule preparations, etc., can solve problems such as the method of not finding chitosan microspheres, and achieve easy industrial production, strong structure controllability, The effect of low production cost
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Embodiment 1
[0025] Under mechanical stirring, add 1g of chitosan into 9.8wt% dilute sulfuric acid aqueous solution, heat at 90°C for 1h with microwave, after the reaction is finished, cool the filtrate obtained by filtering while it is hot to room temperature, centrifuge the generated precipitate, and wash with water After freeze-drying, oblate chitosan microspheres were obtained.
[0026] The FTIR, XRD and SEM images of the product are shown in Figure 1-3 . in, figure 1 a is the FTIR figure of untreated chitosan; figure 1 B is the FTIR figure of the chitosan microsphere prepared by embodiment 1; figure 2 a is the XRD pattern of untreated chitosan; figure 2 B is the XRD figure of the chitosan microsphere prepared in embodiment 1.
[0027] From figure 1 It can be seen that the chitosan microspheres in ~3400cm -1 The broad peak at is the stretching vibration of O-H and N-H, ~2900cm -1 The peak at is produced by the stretching vibration of C-H, ~1524cm -1 The peak at is NH 3 ...
Embodiment 2
[0031] Under mechanical stirring, add 1g of chitosan into 11.8wt% dilute sulfuric acid aqueous solution, heat at 90°C for 1h with microwave, after the reaction is finished, cool the filtrate obtained by filtering while it is hot to room temperature, centrifuge the generated precipitate, and wash with water After freeze-drying, the chitosan microspheres with concave oblate shape in the center are obtained. From the SEM image ( Figure 4 ) It can be seen that the average particle size is 3.5 μm and the average thickness is 1.5 μm.
Embodiment 3
[0033] Under mechanical stirring, add 1g of chitosan into 13.8wt% dilute sulfuric acid aqueous solution, heat at 90°C for 1h with microwave, after the reaction is finished, cool the filtrate obtained by filtering while it is hot to room temperature, centrifuge the generated precipitate, and wash with water After freeze-drying, cake-like chitosan microspheres were obtained. From the SEM image ( Figure 5 ) It can be seen that the average particle size is 2 μm and the average thickness is 0.7 μm.
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