Pharmaceutical composition containing solifenacin succinate

A technology of solifenacin succinate and a composition, which can be applied in the directions of drug combinations, active ingredients of heterocyclic compounds, and medical preparations of non-active ingredients, etc., can solve the problems of poor dissolution of solifenacin succinate tablets and the like

Active Publication Date: 2015-09-30
SICHUAN GOWELL PHARMA
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0011] Using the prior art prescription, the solifenacin succinate tablet prepared by

Method used

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  • Pharmaceutical composition containing solifenacin succinate
  • Pharmaceutical composition containing solifenacin succinate
  • Pharmaceutical composition containing solifenacin succinate

Examples

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Embodiment Construction

[0105] Below in conjunction with specific embodiment, further illustrate the present invention. But these examples are only limited to illustrate the present invention rather than further limiting the protection scope of the present invention.

[0106] composition Content (mg / tablet) weight percentage Solifenacin Succinate 4.5 1.5wt% Direct Compressed Lactose Tablettose 70 270 90wt% Sodium carboxymethyl starch 3.5 1.17wt% Highly substituted hydroxypropyl cellulose 15 5.33wt% Micropowder silica gel 6 2wt%

[0107] Weigh the required raw and auxiliary materials according to the prescription amount, first mix solifenacin succinate with sodium carboxymethyl starch and high-substituted hydroxypropyl cellulose, then add 10% direct compression lactose, and add 20% of Directly compress lactose, mix evenly, then add 30% direct-compressed lactose for mixing, add the remaining direct-compressed lactose, mix and pass through a 50-me...

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Abstract

The invention relates to a pharmaceutical composition containing solifenacin succinate. The pharmaceutical composition is characterized by simultaneously containing direct compression lactose, sodium carboxymethyl starch, a binder and a lubricating agent. The invention also discloses a preparation method, namely a direct powder compression method of the pharmaceutical composition. The pharmaceutical composition and the preparation method thereof are not influenced by water in the preparation process, the pharmaceutical composition is low in impurity content and better in drug dissolubility, and the preparation method is more suitable for industrial production.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a pharmaceutical composition containing solifenacin succinate and a preparation method thereof. Background technique [0002] Solifenacin Succinate, 1-azabicyclo[2.2.2]octane-8-yl-(1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2 - formate succinate) is a new generation of M 3 Receptor antagonist, acts on the M receptor on the detrusor muscle, reduces the overactivity of the detrusor muscle, thereby relieving symptoms such as urgency, frequency and urge urinary incontinence caused by overactive bladder muscle, compared with similar drugs , which has the highest selectivity for the bladder, so it has stronger curative effect, fewer side effects, and better tolerance and compliance of patients. The first-line treatment drugs recommended in the treatment guidelines. [0003] The original manufacturer of solifenacin succinate is Astellas Corporation of Japan. The product was first launched...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/28A61K31/49A61K47/36A61K47/26A61P13/10
Inventor 蒋代财王理黄毅郭礼新郭晖
Owner SICHUAN GOWELL PHARMA
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