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Production method of swine mycoplasmal pneumonia inactivated vaccine

A technology of inactivated vaccines and Mycoplasma suis, which is applied in the direction of bacterial antigen components and antibacterial drugs, and can solve the problems of late start of inactivated vaccines

Active Publication Date: 2015-09-30
北京中海生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

my country is in a leading position in the development of live vaccines, but it started relatively late in the development of inactivated vaccines

Method used

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  • Production method of swine mycoplasmal pneumonia inactivated vaccine
  • Production method of swine mycoplasmal pneumonia inactivated vaccine
  • Production method of swine mycoplasmal pneumonia inactivated vaccine

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Experimental program
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Embodiment Construction

[0018] This strain is prepared by inoculating Lps-5 medium with S strain of Mycoplasma hyopneumoniae, harvesting the culture, adding an appropriate amount of adjuvant, and emulsifying. For the prevention of swine mycoplasma pneumonia (commonly known as swine panting disease).

[0019] 1 strain

[0020] (1) The strain used to manufacture this product is Mycoplasma hyopneumoniae (Mycoplasma hyopneumoniae) S strain, which was isolated and identified by Beijing Zhonghai Biotechnology Co., Ltd.; Preserved at the General Microbiology Center of China Committee for the Collection of Microbial Cultures, No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences, and the preservation number is CGMCC No.10095. The bacterial species used for efficacy testing is Mycoplasma hyopneumoniae JN strain, provided by China Veterinary Drug Control Institute.

[0021] (2) The strain standard for the production of Mycoplasma hyopneumoniae S s...

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Abstract

The invention relates to a production method of a swine mycoplasmal pneumonia inactivated vaccine. The swine mycoplasmal pneumonia inactivated vaccine disclosed by the invention is produced by successfully separating a mycoplasma hyopneumoniae S strain having good immunogenicity and used as a production bacterial strain, and researching a proper cultural method, an inactivating process and a proper immunologic adjuvant by using a high-efficiency culture medium. After being used for immunized piglets, the inactivated vaccine produced by the invention can obtain good immune protective efficacy.

Description

technical field [0001] The invention relates to an inactivated vaccine for preventing infectious diseases of pigs, and the patent belongs to the technical field of veterinary biological products. Background technique [0002] Mycoplasma pneumoniae of swine (MPS), also known as porcine endemic pneumonia (Enzootic pneumoniae of Swine, EPS), commonly known as swine panting disease, is a chronic contact respiratory disease caused by Mycoplasma hyopneumoniae Infectious disease, the main symptoms are cough and wheezing, growth retardation, low feed conversion rate. The disease has high morbidity and low mortality, and is widely distributed all over the world. It is one of the most important diseases that cause economic losses in pig farming worldwide. [0003] Mycoplasma hyopneumoniae has all the morphological characteristics of typical mycoplasma, and the cells without cell walls have various shapes. Under the electron microscope, spherical, ring-shaped, filamentous and point-sh...

Claims

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Application Information

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IPC IPC(8): A61K39/02A61P31/04
Inventor 孙晔吴金冯忠泽沈青春李秋菊魏晶晶李聪研孙亚波宋潇婷史文艳
Owner 北京中海生物科技有限公司
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