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Wild jujube seeds extract and preparation method and use thereof

A kind of jujube seed extract and technology of jujube seed, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of drug resistance of bacteria, difficulty in treating and preventing bacterial infectious diseases, etc., and achieve low toxicity, Good curative or preventive effect, effect of ensuring food safety

Active Publication Date: 2009-06-17
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the abuse of antibiotics, the emergence of drug resistance of these bacteria has made it more difficult to treat and prevent bacterial infectious diseases.

Method used

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  • Wild jujube seeds extract and preparation method and use thereof
  • Wild jujube seeds extract and preparation method and use thereof
  • Wild jujube seeds extract and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation of embodiment 1 Suanzaoren extract

[0026] Grind 100g of jujube kernels and pass through a 10-mesh sieve. Add 6 times the amount (ml / g) of petroleum ether to the screened matter and soak for 6 hours to degrease. Degrease 6 times. After the degreasing is complete, evaporate the petroleum ether to dryness. Then add 75% alcohol of 6 times of amount (ml / g) to the dregs to soak and extract, soak for 4 hours each time, extract 4 times continuously, add 3 times of amount (ml / g) of water after removing the alcohol and stir to mix. Uniform, then add 4 times of amount (ml / g) water-saturated n-butanol therein and extract continuously 4 times, and concentrate, make the Suanzaoren jelly paste of 5g, its extraction rate is 5%.

[0027] Qualitative and quantitative determination of jujuboside A and B in jujube seed extract

[0028] Qualitative experiment:

[0029] Take 2g of the above Jujube Seed Gum Paste, add 25ml of water-saturated n-butanol solution, heat to dis...

Embodiment 2

[0053] Example 2 Preparation of Jujube Seed Extract

[0054] Grind 100g of jujube kernels and pass through a 10-mesh sieve, add 2 times the amount (ml / g) of petroleum ether to the sieved matter, soak and degrease for 3 hours, degrease 8 times, evaporate the petroleum ether to dry after the degreasing is complete. Then add 73% alcohol of 4 times the amount (ml / g) of the dregs to soak and extract, soak for 1 hour each time, and extract 7 times continuously, add 3 times the amount (ml / g) of water after removing the alcohol and stir to mix. homogeneous, then add 2 times the amount (ml / g) of water-saturated n-butanol to extract continuously for 2 times, and concentrate to obtain 4.1g of Suanzaoren jelly paste, with an extraction rate of 4.1%.

[0055] Qualitative and quantitative determination of jujuboside A and B in jujube seed extract

[0056] Qualitative experiment:

[0057] The assay method of qualitative experiment is the same as embodiment 1, and in the obtained test sampl...

Embodiment 3

[0066] Example 3 Preparation of Jujube Seed Extract

[0067] Grind 150g of jujube kernels and pass through a 10-mesh sieve. Add 8 times the amount (ml / g) of petroleum ether to the screened matter and soak for 7 hours to degrease. Degrease 5 times. After the degreasing is complete, evaporate the petroleum ether to dryness. Then add 8 times the amount (ml / g) of 71% alcohol to the dregs to soak and extract, soak for 2 hours each time, and extract 2 times continuously, add 5 times the amount (ml / g) of water after removing the alcohol and stir to mix. homogeneous, then add 6 times of amount (ml / g) of water-saturated n-butanol to extract continuously for 6 times, and concentrate to obtain 9.6g Suanzaoren jelly paste, with an extraction rate of 6.4%.

[0068] Qualitative and quantitative determination of jujuboside A and B in jujube seed extract

[0069] Qualitative experiment:

[0070] The assay method of qualitative experiment is the same as embodiment 1, and in the obtained test...

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Abstract

The invention relates to a wild jujube seed extract which is prepared by the following method: crushing wild jujube seeds, screening, soaking with ethanol to extract, after removing alcohol, adding water, uniformly stirring, leaching with aqueous n-butylalcohol, lastly concentrating and airing. The wild jujube seed extract of the invention can be prepared into oral liquid, granules, injection or freeze-drying powder injection through routine techniques. The wild jujube seed extract can be used prepare medicament compositions preventing poultry mycoplasma, Escherichia coli, brusal disease virus, avian H9 influenza virus disease, makes up for loss caused by poor preventing effect of existing bacterin in our country, substitutes bacteriophage to prevent and treat poultry resistant virus disease to control prevalence of infectious disease and solve a problem of bacteriophage residue in foods, thus guaranteeing food security and promoting export competitive ability of animal products.

Description

technical field [0001] The invention relates to an extract of Jujube Semen capable of preventing poultry mycoplasma, Escherichia coli, chicken bursal disease and avian lymphoid leukemia new subtype virus diseases, as well as its preparation method and application. Background technique [0002] Since the beginning of the 21st century, major livestock and poultry diseases have continued to break out all over the world, which not only seriously hindered the healthy development of animal husbandry, but also caused a series of public health emergencies. Major epidemics such as coccidiosis and foot-and-mouth disease have caused great harm to people's health and social stability. Therefore, the research and creation of new biological veterinary drugs has become a major national demand to ensure the development of my country's animal husbandry, maintain people's health and life safety, maintain social stability and promote economic development. [0003] Ziziphus jujuba Mill.var.spi...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61P31/00A61P31/04A61P31/14A61P35/02
Inventor 何诚李应超张发明李树梅何云
Owner CHINA AGRI UNIV
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