Hollow mesoporous copper sulfide compound modified by hyaluronic acid and preparation method and application thereof

Abstract

The invention relates to a hollow mesoporous copper sulfide compound modified by hyaluronic acid and a preparation method and application thereof, and the problems that the water solubility of copper sulfide is poor, the targeting property is poor, and the biological compatibility is low can be effectively solved. The method comprises the steps that hollow mesoporous copper sulfide nanoparticles are bonded to the surfaces of copper sulfide nanoparticles, mercaptoethylamine are connected to the bonded copper sulfide nanoparticles, hyaluronic acid modification is conducted through amido bond reactions, and the hollow mesoporous copper sulfide compound modified by the hyaluronic acid is formed; the particle diameter ranges from 50 nm to 250 nm, the mass ratio of the hyaluronic acid to the hollow mesoporous copper sulfide is 1-3 to 3, and the molecular weight of the hyaluronic acid ranges from 40 kDa to 400 kDa. According to the hollow mesoporous copper sulfide compound modified by the hyaluronic acid and the preparation method and application thereof, the synthesis technology is easy, the non-targeting problems of a traditional light thermal therapy technology and a chemotherapy technology are solved, and damage to normal tissues is reduced in the therapeutic process; the hollow mesoporous copper sulfide compound modified by the hyaluronic acid and the preparation method and application thereof have the advantages of being efficient, controllable, strong in drug loading property, high in biological compatibility, good in targeting property, low in cost and the like, and the economic and social benefits are great.

Description

technical field

[0001] The invention relates to medicine, in particular to a hyaluronic acid-modified hollow mesoporous copper sulfide compound and its preparation method and application. Background technique

[0002] At present, as a safe and efficient pharmaceutical carrier, nanomaterials show broad development space in the treatment of tumors. As carrier materials, they should have the characteristics of small particle size, low toxicity, good biocompatibility, and stable performance. . Hollow mesoporous copper sulfide has a unique cage-like structure, outstanding drug-loading capacity, small particle size, stable physical and chemical properties, and low toxicity to organisms. Its water solubility and targeting can be enhanced by modifying some groups. It is beneficial for the carrier to flow with the blood in the living body to reach the tumor site, reduce the damage to normal tissues, and improve the therapeutic effect.

[0003] Copper sulfide nanoparticles, as a new...

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