176 results about "Mercaptoethylamines" patented technology

The invention discloses a colorimetric analysis method for simply and rapidly detecting mercury ions in an aqueous solution. According to the method, the characteristic of high light absorption coefficient of nanogold is utilized, the nanogold is used as a chromogenic signal component, and simultaneously mercaptoethylamine is used as a specificity identification component. The colorimetric analysis method has the advantages of being low in cost, simple in operation, convenient and rapid. The modified nanogold is stable, high in resistance to high concentration salt ions, slightly interfered by external factors and suitable for being popularized and applied.

The invention firstly adopts mercaptoethylamine to trigger ring opening polymerization of L-glutamic acid-gamma-benzyl ester-N-carboxylic acid anhydride (BLG-NCA) to prepare mercaptyl-terminated (L-glutamic acid-gamma-benzyl ester) polymer, the mercaptyl-terminated (L-glutamic acid-gamma-benzyl ester) polymer is used as a macromolecular chain transfer agent to perform free radical polymerization with activated monomer polyethylene glycol metacrylic acid ester (MAPEG, Mn is equal to 475g/mol), and thereby amphiphilic poly(L-glutamic acid)-b-polyethylene glycol is obtained; cystamine is used for crosslinking L-glutamic acid-gamma-benzyl ester therein, meanwhile the residual gamma-benzyl ester groups are converted into carboxylic acid groups and adriamycin amycin is statically loaded, and thereby the nano micelle is formed by self-assembling in aqueous solution.

The invention provides a method for preparing gold nano particles. The method particularly comprises the following steps of: at room temperature, adding perchloric acid gold into distilled water to obtain 10<-2>mol/L aqueous solution of the perchloric acid gold; adding sodium citrate and sodium borohydride while stirring the aqueous solution; continuously stirring the mixed solution for 0.5 to 2 hours; and adding 3*10<-5>mol/L aqueous solution of mercaptoethylamine to obtain mercaptoethylamine-modified gold nano particles, wherein the weight ratio of the distilled water, the aqueous solution of the perchloric acid gold, the sodium citrate, the sodium borohydride to the aqueous solution of the mercaptoethylamine is 1:(0.008-0.01): (0.032-0.04):(0.04-0.12):(0.005-0.05). The method is simple and has high operability; and by the change of visible color of the gold nano particles prepared by the method, cyhalothrin in esbiothrin pesticides can be quickly identified and detected, and the detection limit reaches national standard value.

The invention discloses a trace nitroaromatic explosive visual inspection quantum dot test paper and a preparation method thereof. The preparation method comprises three steps that: CdTe quantum dots modified by mercaptoethylamine are prepared; CdTe quantum dots wrapped by thioglycolic acid are prepared; and CA-CdTe quantum dot solution and TGA-CdTe quantum dot solution are mixed and loaded on the surface of a filter paper. According to the invention, amino-comprising mercaptoethylamine modified on the surface of CA-CdTe quantum dots are utilized. The electron-rich amino on the surface of CA-CdTe quantum dots serve as an electron donor, and a meisenheimer composite is formed through the acid-base ion pair effect between the electron donor and the electron-deficient aromatic nitro explosive. Based on a direct charge transfer principle, fluorescence of the CA-CdTe quantum dots is quenched, such that nitroaromatic explosive visual inspection is realized. The TGA-CdTe quantum dots serve as an internal reference, such that sensitivity of naked eyes upon slight color change is enhanced. According to the invention, the CA-CdTe quantum dots and TGA-CdTe quantum dots are synthesized through aqueous phase reflux reduction. The preparation method is simple, cost is low, and quantum dot yield is high.

The invention discloses a urease inhibitor determination method based on a fluorescence gold nano cluster. The urease inhibitor determination method is characterized in that urea is catalyzed to generate ammonium and carbon dioxide by utilizing the specificity of urease, the pH value of the system can be increased through the newly generated ammonium, the fluorescence of the gold nano cluster protected by N-acetyl-L-cysteine is extinguished, the urease inhibitor can prevent the process that the urea is decomposed by the catalyzing of the urease, the extinguishment of the fluorescence is inhibited, and the urease inhibitor determination method can be used for detecting the urease inhibitor. An F650 value is determined, the inhabitation rate is calculated, and the contents of IC50 of cysteamine and p-benzoquinone, respectively 2.8mu mol/L and 11.9mu mol/L, can be obtained through the fitting by software. The urease inhibitor determination method can be used for the high-throughput screening of the urease inhibitor.

The invention discloses a preparation method of a stable type compound nano anti-wearing agent, and belongs to the technical field of preparation of lubricating oil additives. The preparation method comprises the following steps: firstly, enabling nano molybdenum disulfide to react with n-butyl lithium to obtain pretreated molybdenum disulfide; carrying out ultrasonic dispersion on the pretreated molybdenum disulfide and mercaptoethylamine; inserting the n-butyl lithium into a molybdenum disulfide sheet layer; stripping the molybdenum disulfide sheet layer in an ultrasonic treatment process, so as to expose an active group of the molybdenum disulfide; loading the mercaptoethylamine, and reacting with maleic anhydride and ethanol, so as to increase the lipophilic property of the molybdenum disulfide; coating the surface of the molybdenum disulfide with maleate, so that molybdenum disulfide powder is difficultly gathered, and the stability and uniformity are improved; finally, stirring with modified nano boron nitride, dispersing, and drying to obtain the anti-wearing agent. The anti-wearing agent prepared by the method has relatively good anti-wearing performance, and also has excellent stability and dispersity; the anti-wearing agent has no layered precipitation and no nano agglomeration phenomenon; after the anti-wearing agent is added into lubricating oil, the lubricating performance can be remarkably improved; the anti-wearing agent has relatively good application prospect.

The invention relates to a hollow mesoporous copper sulfide compound modified by hyaluronic acid and a preparation method and application thereof, and the problems that the water solubility of copper sulfide is poor, the targeting property is poor, and the biological compatibility is low can be effectively solved. The method comprises the steps that hollow mesoporous copper sulfide nanoparticles are bonded to the surfaces of copper sulfide nanoparticles, mercaptoethylamine are connected to the bonded copper sulfide nanoparticles, hyaluronic acid modification is conducted through amido bond reactions, and the hollow mesoporous copper sulfide compound modified by the hyaluronic acid is formed; the particle diameter ranges from 50 nm to 250 nm, the mass ratio of the hyaluronic acid to the hollow mesoporous copper sulfide is 1-3 to 3, and the molecular weight of the hyaluronic acid ranges from 40 kDa to 400 kDa. According to the hollow mesoporous copper sulfide compound modified by the hyaluronic acid and the preparation method and application thereof, the synthesis technology is easy, the non-targeting problems of a traditional light thermal therapy technology and a chemotherapy technology are solved, and damage to normal tissues is reduced in the therapeutic process; the hollow mesoporous copper sulfide compound modified by the hyaluronic acid and the preparation method and application thereof have the advantages of being efficient, controllable, strong in drug loading property, high in biological compatibility, good in targeting property, low in cost and the like, and the economic and social benefits are great.

The invention discloses fluorescent molecular TPCA and a preparation method thereof. The fluorescent molecular is 5-oxo-3,5-dihydro-2H-thiazole [3,2-a]pyridine-7-carboxylic acid, for short, TPCA. The preparation method comprises the steps that 0.01-10 g of citric acid and 0.001-1 g of mercaptoethylamine are mixed in 5-100 mL of water, evenly stirred and then transferred to a hydrothermal reaction kettle, after a hydrothermal reaction is carried out under 100-300 DEG C for 0.1-100 h, the mixture is cooled to be at the room temperature, and a TPCA solution is obtained; the TPCA solution is subjected to still standing, filtering, washing and drying, and then TPCA solid is obtained. The technological method is simple and rapid, the reaction condition is gentle and friendly to environment, adopted raw materials are cheap and easy to obtain, and catalyst is not needed. The prepared TPCA has solubility in water and organic solvents, the fluorescence efficiency in water can reach 90%, and the fluorescent molecular TPCA can be widely applied to the fields of fluorescent printing, fluorescent composites, fluorescence imaging, fluorescence detection probes, organic light emitting devices and the like.

The invention discloses a high-precision patterned stretchable electrode and a preparation method thereof. The high-precision patterned stretchable electrode is a patterned electrode attached to an elastic substrate. The patterned electrode is a metal electrode connected with a carbon nano tube. The metal electrode is a gold electrode. The metal electrode is connected with the carbon nano tube through mercaptoethylamine. The high-precision patterned stretchable electrode is prepared by the method provided in the invention. The method comprises the following steps: evaporating metal on a substrate provided with an electrode pattern to obtain a metal electrode; spraying a carbon nano tube on the surface of the metal electrode; preparing an elastic substrate on the surface of the carbon nanotube, and stripping the elastic substrate from the substrate. According to the patterned stretchable electrode provided by the invention, the advantages of high conductivity of a traditional gold electrode and high aspect ratio and large specific surface area of a carbon nano tube are combined. The advantage complementation is fully realized, and the high-precision patterned stretchable electrodewith high tensile property and good conductivity is prepared.

The invention particularly discloses an intelligent targeting and environmental dual-responsibility siRNA [short interfering RNA (ribonucleic acid)] delivery system for tumor, a preparation method and application. The siRNA delivery system is characterized in that siRNA is concentrated and compounded in nanometer particle nucleuses by the aid of acid-sensitive amphiphilic three-block polymers, and intermolecular disulfide bonds are formed by PAsp(MEA) on sub-surfaces, so that the siRNA can be protected, and the intelligent targeting and environmental dual-responsibility siRNA delivery system can respond to release of the siRNA in reductive cytoplasm. The acid-sensitive amphiphilic three-block polymers comprise polyethylene glycol block-intermediate block-acid-sensitive block three-block copolymers, intermediate blocks comprise polyaspartate acyl mercaptoethylamine, and acid-sensitive blocks comprise poly (diisopropyl amine) ethyl methacrylate. The intelligent targeting and environmental dual-responsibility siRNA delivery system, the preparation method and the application have the advantages that the siRNA delivery system can be applied to preparing intelligent targeting siRNA nanometer medicines for the tumor and is low in N/P ratio dependence degree, and the siRNA can be quickly and completely released at targets; a novel idea can be provided for gene delivery systems, and the intelligent targeting and environmental dual-responsibility siRNA delivery system, the preparation method and the application have important significance on preparing clinical diagnosis and treatment medicines for the tumor.

The invention discloses a preparation method and application of a polydopamine/nano molybdenum disulfide photocatalyst. The preparation method comprises the following steps: first, preparing molybdenum disulfide nano-sheets by a lithium ion intercalation method; then adding mercaptoethylamine for modification to obtain aminated molybdenum disulfide; then introducing a dopamine monomer into the reaction system to mix uniformly with the aminated molybdenum disulfide; and finally, synthesizing a polydopamine/nano molybdenum disulfide composite by self-condensation of dopamine on the surface of the aminated molybdenum disulfide. Due to the introduction of polydopamine into the composite catalyst prepared by the method provided by the invention, the photocatalytic performance of the composite catalyst is greatly improved.

The invention relates to a pharmaceutical composition of hyaluronic acid modified magnetic hollow mesoporous copper sulfide as well as a preparation method and application of the pharmaceutical composition; the pharmaceutical composition is capable of effectively solving the problems of guaranteeing good biocompatibility, strong magnetic targeting and low toxic and side effects so as to enhance a tumor treatment effect. The preparation method comprises the following steps: loading an antineoplastic drug on aminated copper sulfide obtained from a reaction between hollow mesoporous copper sulfide nanoparticles and mercaptoethylamine; adsorbing ferroferric oxide nanoparticles to the surface of the copper sulfide through an electrostatic effect; and modifying hyaluronic acid on the surface through an amide bond reaction, so as to obtain the pharmaceutical composition of hyaluronic acid modified magnetic hollow mesoporous copper sulfide, wherein the mass content ratio of the ferroferric oxide to the copper sulfide is at (1-8): 1; and the grain size of the magnetic hollow mesoporous copper sulfide is 50-300nm. The preparation method disclosed by the invention is convenient in operation, and is stable and reliable; the pharmaceutical composition has the advantages of good biocompatibility, strong magnetic targeting, low toxic and side effects and the like; and the pharmaceutical composition can take the effects of thermal therapy, tumor diagnosis, magnetic field sustained and controlled drug release and the like in the aspect of tumor treatment.

The invention discloses thymidine derivates, belonging to the technical field of radiopharmaceutical chemistry and clinical nuclear medicine. A molecular formula of the derivates is N<3>-{N'-[(2-mercaptoethylamine)acetyl]-2-aminoethylsulphydryl-1-hexoamide}-thymidine (short for NHT). The invention further provides a preparation method for the thymidine derivates, as well as applications of the thymidine derivates in preparing tumor developing agents as ligand with <99m>Tc to form complex. Marker <99m>Tc in <99m>Tc-NHT has high radiochemical purity; lipd/water partition coefficient logP is 0.76; the stability is good; the safety of animal experiment is higher; and the ratios of radioactivity absorbed by tumor with radioactivity absorbed by muscle, radioactivity absorbed by bone and radioactivity absorbed by blood according to ID/g by percent are respectively 4.41, 2.45 and 1.51, therefore, the thymidine derivates can be used as a novel tumor developer for tumor diagnosis.

The invention discloses biomass-based high-efficiency sulfur-nitrogen-doped carbon quantum dots. The biomass-based high-efficiency sulfur-nitrogen-doped carbon quantum dots are prepared from the following components in weight and volume proportions: 8-14g of a crude chlorophyll extract, 1-6g of citric acid, 0.5-2.5g of mercaptoethylamine, 120-150mL of deionized water and 0.01-0.24g of magnesium chloride. A preparation method of the biomass-based high-efficiency sulfur-nitrogen-doped carbon quantum dots comprises the following steps: extracting the crude chlorophyll extract from plant wastes byusing ethanol, then stirring the raw materials until full dissolution to obtain a mixture, then placing in a stainless steel reaction kettle for a hydrothermal reaction, filtering and purifying to obtain a product. Compared with the prior art, the invention has the advantages as follows: the main raw materials are derived from the plant wastes (environment-friendly); the obtained biomass-based high-efficiency sulfur-nitrogen-doped carbon quantum dots have high biosafety and high fluorescence intensity and can be applied to detection of Cu<2+> and Fe<3+> ions; in addition, when the mass percentage concentration of the biomass-based high-efficiency sulfur-nitrogen-doped carbon quantum dots is 50ng/mL, the fluorescence intensity is very high and the biomass-based high-efficiency sulfur-nitrogen-doped carbon quantum dots can be applied to the field of biomedical imaging, so that the application value is expanded.

The invention relates to a method for binding and fixing an ionic type iridium coordination compound based on a covalent bond, belonging to the field of electrochemiluminescence detection. The method comprises the following steps: firstly, preparing an ionic type iridium coordination compound hexafluorophosphoric acid di(6-methyl-2,4-(4'-methoxy)-diphenyl quinoline (4,4'-dicarboxyl-2,2'-dipyridyl) coordination iridium ((dpq-OCH3)2Ir(dcbpy)+PF6-) with carboxyl by adopting an organic synthesis method, respectively adding 1-ethyl-(3-dimethyl aminopropyl) carbonyl diimine (EDC) and N-hydroxyl succinimide (NHS) to activate the carboxyl, then, adding mercaptoethylamine to stir and react with the carboxyl; and then, preparing nanogold on the surface of a glassy carbon electrode by adopting an electrodeposition method, inserting a prepared electrode into the solution system, and forming an Au-S covalent bond through chemical reaction of the two, and loading the ionic type iridium coordination compound on the electrode. An electrochemiluminescence solid-phase electrode prepared by the method has good response for coreactant dibutyaminoethanol (DBAE).

The invention discloses vanadium dioxide/zinc sulfide composite powder with a core-shell structure and a preparation method of the composite powder. A core of the composite powder is of vanadium dioxide powder, and a shell of the composite powder is of zinc sulfide. The preparation method of the vanadium dioxide/zinc sulfide composite powder with the core-shell structure comprises the steps of (1) synthesizing monoclinic phase vanadium dioxide powder through one step hydro thermal method; (2) preparing a mixed buffer solution of zinc acetate/acetic acid/sodium acetate; (3) adding a surfactant and the vanadium dioxide powder into the buffer solution, then stirring, adding mercaptoethylamine, heating, and cooling, so as to obtain a product, namely turbid liquid; (4) performing centrifugation, washing and vacuum drying on the product. The obtained vanadium dioxide/zinc sulfide powder can maintain infrared adaptive feature, compatible adaptive camouflage of visible light/infrared is realized, more excellent camouflage protective property and heat stability are achieved, which enable the vanadium dioxide/zinc sulfide composite powder with the core-shell structure has wide application prospect in the field of camouflage and protection.

The invention discloses a water-soluble iron carbonyl compound, and a preparation method and an application thereof. The compound has a structural formula represented by the formula (1). When the compound is subjected to a reaction with mercaptoethylamine, CO can be released. The compound provided by the invention has good water solubility and appropriate stability. Metal ions and organic ligands involved in the reaction have good biocompatibility. Residual substances after CO releasing are harmless or slightly toxic to bodies. The timing and rate of CO releasing are easy to control.

The invention discloses a sulfide heavy metal chelating agent N1,N2,N4,N5-tetra(2-sulfydrylethyl)1,2,4,5-pyromellitic formamide and a preparation method thereof. The preparation method of the chelating agent comprises the following steps of: dissolving certain mol ratios of mercaptoethylamine hydrochloride and pyromellitic formic anhydride into dimethylformamide (DMF) at a certain temperature; agitating to react for a period of time and filtering to obtain the N1,N2,N4,N5-tetra(2-sulfydrylethyl)1,2,4,5-pyromellitic formamide. The sulfide heavy metal chelating agent provided by the invention is used for treating industrial wastewater containing heavy metal ions and can effectively avoid the generation of hydrogen sulfide; the sulfide heavy metal chelating agent can be rapidly reacted with various heavy metal ions in the wastewater at a room temperature to generate water-dissoluble sulfide sediment; the sediment is large in grain size and compact in flocs, so that the deposition time is shortened, heavy metal can be recycled from residues, and secondary pollution is not easy to happen. The sulfide heavy metal chelating agent N1,N2,N4,N5-tetra(2-sulfydrylethyl)1,2,4,5-pyromellitic formamide and the preparation method thereof, provided by the invention, have the advantages of simple preparation process, convenience for use and good treatment effect.

The invention relates to a sludge environment-friendly curing agent and belongs to the field of curing agent. In the invention, firstly, vermiculite powder is soaked in and activated by a salt solution and then is modified with mercaptoethylamine, so that a large number of tiny flake-like products are formed on the surface of a cured product and are interlaced layer by layer, thus forming a compact structure; the curing agent is then contacted with sludge under effect of water pressure, so that a part of the curing agent is embedded in the sludge to slowly achieve the curing effect; with slight stirring, the curing effect is further improved. The curing agent is stable and durably and has multilayer effect. By crushing watermelon peel and banana peel and mixing the watermelon peel and banana peel with active sludge and the like for fermentation, a plurality of organic acids are generated and can be chemically bonded to silicon hydroxyl groups in the sludge, thus enhancing adhesion force of the sludge. Besides, sodium silicate has effect of soil adhesion and curing, so that a water stabilizing aggregate is formed in interior. The structure releases heat and water under effect of quick lime, thus curing the sludge strongly. The curing agent also can fill the gaps in the sludge, thus improving sludge curing performance. The product solves the problem of poor curing performance ofsludge curing agents in the prior art.

The invention discloses an electrochemical method for detecting trace trivalent inorganic arsenic by using a mercaptoethylamine modified electrode, and relates to the field of electrochemical detection. The method solves the problems of complex process, long detection time, poor reproducibility and poor interference resistance of the conventional electrochemical methods for detecting the trivalent arsenic. According to the method, the mercaptoethylamine modified gold electrode serving as a working electrode, silver-silver chloride serving as a reference electrode and platinum serving as a counter electrode form a three-electrode system; and constant potential deposition is performed by applying a voltage through differential pulse voltammetry, dissolved oxidation reaction of arsenic is performed on the surface of the mercaptoethylamine modified gold electrode, and the trivalent arsenic is detected in a phosphate buffer solution. The electrode preparation method is simple, an electrochemical polarization process under high potential is avoided, the sensitivity and the reproducibility of the sensing detection are improved, and the problem of interference of copper ions is solved; and the detection time is short, the detection limit can reach 0.02mugL<-1>, and the method can be used for detecting the arsenic in a practical sample.

The invention belongs to the field of cosmetology and hairdressing and discloses a green and environment-friendly hair shaping and finishing agent as well as a preparation method and application thereof. The hair shaping and finishing agent is prepared from the following raw materials in parts by mass: 3-6 parts of citric acid, 1-3 parts of chlorophyll a, 0.1-0.8 part of mercaptoethylamine and 0.01-0.1 part of sodium selenite. The preparation method comprises the following steps of: respectively dissolving the citric acid and the chlorophyll a in pure water, mixing, then adding the mercaptoethylamine and the sodium selenite, and dissolving to obtain a mixed solution; transferring the mixed solution into a polytetrafluoroethylene lining, putting the lining into a stainless steel reaction kettle, putting the stainless steel reaction kettle in a drying oven for carrying out hydrothermal reaction for 120-240 minutes at 140-200 DEG C; taking the solution out after the temperature in the drying oven is reduced to room temperature, centrifuging for 10-30 minutes under the condition of 4000-10000 r/min, taking supernatant liquid, dialyzing the supernatant liquid for 2-4 days by using a 200Da dialysis bag, and then carrying out freeze-drying to obtain the environment-friendly hair shaping and finishing agent.

The invention discloses a thiol acrylic fiber material and a synthesis method thereof and belongs to the technical field of high polymer materials. The method comprises the following steps: taking an acrylic fiber as a raw material fiber, introducing a thiol through a chemical grafting reaction between the acrylic fiber and an organic compound (comprising cysteine, mercaptoethylamine, o-amido thiophenol and the like) containing amido and thiol, so as to obtain a novel functional fiber material. The functional fiber material is high in group content, keeps good form and strength and has application prospects in aspects such as functional textiles, water and air purification, chemical substance separation and extraction and the like. The synthesis method is simple in process, mild in conditions and easy to control, the used chemical raw materials are non-toxic or low-toxic, the raw material consumption is low in reaction process, no toxic by-product is generated, and the method is an environment-friendly synthesis method.