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Traditional Chinese medicine composition for preparing color Doppler ultrasound contrast agent, applications and preparation method thereof

A technology of composition and contrast agent, which is applied in the direction of drug combination, medical formula, echo/ultrasound imaging agent, etc., can solve the problems of unclear display of gastric wall layers, increased patient pain, strong gastric acid reaction, etc., to achieve clear and visible layers, No toxic side effects, clear image effect

Inactive Publication Date: 2015-10-21
王桂霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, this kind of contrast agent adds an extra burden to the gastrointestinal tract and increases the pain of the patient.
[0004] For B-ultrasound gastrointestinal imaging aids, the prior art records that the imaging aids prepared by mixing 80% of sea octopus fine powder and 20% of Bletilla striata 100-mesh fine powder have astringent and acid-stopping effects on gastrointestinal diseases, but The disadvantage is that after taking the contrast agent, the strong echo light spots are not enough, the reflection effect is not good, and the layers of the stomach wall are not clear; after the patient takes the contrast agent, the gastric acid reaction is strong, and there is pain and discomfort, which is not conducive to stomach Contrast-enhanced ultrasonography of the intestine, this contrast agent cannot be used in patients with gastric bleeding
This composition still contains barium sulfate and cannot be used as a therapeutic drug for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The acute toxicity test of medicine of the present invention to mice:

[0051] Get 12 mice of 20 ± 2g, half male and half male, and use the medicine of the present invention for one-time gavage administration at 8 o'clock in the morning. As for the number of deaths, the experimental results showed that after the mice were fed with the drug, the movement decreased first, and then returned to normal quickly, and no animals died. Give mice 200g / kg orally, calculated by kilogram body weight, which is equivalent to 467 times the daily dosage of an adult, converted according to the animal coefficient, equivalent to more than 50 times the daily dosage of a 70kg adult, and the animal will die within a week. Show that its LD50 must be greater than 200g / kg. The results show that the maximum tolerated dose of administration in mice is above 200 g / kg, and oral administration is very safe. It proves that the present invention is safe for oral administration.

Embodiment 2

[0053] The long-term toxicity test of medicine of the present invention to rat:

[0054] Get 24 SD rats, half male and half male, and are randomly divided into three groups. The high-dose group of the present invention is administered intragastrically with 50 times the drug equivalent to the clinical dosage of adults, and the low-dose group of the present invention is given 20 times the clinical dosage equivalent to adults. Oral administration of drugs; blank control group, given the same amount of distilled water. According to the relevant regulations in the "Guidelines for Preclinical Research of New Chinese Medicines", the rats were gavaged with the highest concentration and the largest gavage volume for 7 days a week for 4 consecutive weeks. All the mice grew well, moved freely, had shiny coats, had normal diet and urine, and gained weight naturally. No obvious toxic reaction was found, nor did the animals die. After examination, the blood routine and blood biochemical in...

Embodiment 3

[0056] The preparation of powder of the present invention:

[0057] Weigh 12kg tortoise shell, 12kg astragalus, 12kg bletilla striata, 12kg sea octopus, 2kg dry alum, 4kg egg shell, 8kg codonopsis, 6kg tangerine peel, 8kg dodder, 4kg talcum powder, dry, crush and pass through 150 sieves; mix well; Flavor agent, 60 ℃ vacuum drying, powder.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine composition for preparing a color Doppler ultrasound contrast agent, applications and a preparation method thereof. The traditional Chinese medicine composition is composed of the following raw materials: turtle shell, radix astragali, bletilla striata, cuttlebone, dried alum, egg shell, radix codonopsis, dried orange peel, semen cuscutae, and talcum powder. The provided traditional Chinese medicine composition can be used as a contrast agent used in the digestive tracts, and also has a pharmacologic effect, so the composition can be used to treat diseases such as gastrointestinal ulcer, gastrointestinal bleeding, and the like in clinic.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition and its application and preparation method, in particular to a color ultrasound image aid and a medicine for treating gastric ulcer. Background technique [0002] Since the human gastrointestinal tract is a hollow organ, in general, the use of color Doppler ultrasound cannot show the layers of the stomach wall well. The use of contrast aids can make the gastric cavity full and can well display the shape of the stomach, the size of the gastric cavity, the layer of the gastric wall, the emptying time, and the location of gastric lesions, as well as the lesions of the small intestine and colon. [0003] At present, the commonly used contrast agents are mainly barium sulfate and iodine preparations. However, existing studies have confirmed that the amount of contrast aids is an independent risk factor for contrast aid nephropathy. In a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K36/898A61P1/04A61P7/04A61K35/57A61K35/618A61K35/586A61K33/12A61K33/06
Inventor 不公告发明人
Owner 王桂霞
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