The invention discloses a disease prevention traditional Chinese medicine combination for Guan dong fish cultivation. The disease prevention traditional Chinese medicine combination is prepared from, by weight, 50-100 parts of Chinese parsnip roots, 40-80 parts of angelica dahurica, 30-70 parts of flos magnolia, 50-100 parts of folium mori, 30-80 parts of Chinese thorowax roots, 25-50 parts of Melia azedarach leaves, 20-50 parts of indigo naturalis, 55-110 parts of rhizoma smilacis glabrae, 50-120 parts of mung bean flour, 40-100 parts of peanut flour, 70-150 parts of soybean flour, 30-70 parts of kaladana, 20-50 parts of eupatorium fortune, 50-100 parts of plantain seeds, 12-30 parts of peppers, 20-40 parts of rabdosia lophanthide and 40-80 parts of galangal. The traditional Chinese medicine combination can improve disease resistance of the Guan dong fish to reduce morbidity and mortality of the fish and can whet the appetite of the Guan dong fish so that the fish can continuously gain weight and grow, and is good in raising benefit, low in price, safe, efficient, and beneficial to popularization, and the raw materials are abundant.