Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of liposome preparation device and preparation method

A technology for preparing devices and liposomes, which is applied in the field of medicine or cosmetics preparation, and can solve the problems of relatively high personnel quality and experience requirements

Active Publication Date: 2018-01-02
胡权
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the preparation of liposomes on the market is all small and medium scale, and the requirements for the quality and experience of personnel are relatively high during the manufacturing process.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of liposome preparation device and preparation method
  • A kind of liposome preparation device and preparation method
  • A kind of liposome preparation device and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Such as figure 1 As shown, the present invention provides a liposome preparation device, including a hydration liquid storage tank 100, an evaporation hydration tank 200, a high-pressure pump 300, an extruder 400 and a filter 500, a hydration liquid storage tank 100 and an evaporation The hydration tank 200 is connected through a connecting pipe, the evaporative hydration tank 200 is connected with the high-pressure pump 300 through a connecting pipe, the high-pressure pump 300 is connected with the extruder 400 through a connecting pipe, and the extruder 400 is connected with the hydration liquid storage tank 100 through a connecting pipe Connection, the high-pressure pump 300 is connected with the filter 500 through a connecting pipe.

[0043] Stirring motors 600 are arranged on the hydration liquid storage tank 100 and the evaporation hydration tank 200 respectively, and stirring paddles are set on the stirring motors, wherein the stirring motor set on the hydration ...

Embodiment 2

[0051] Such as image 3 As shown, the difference between this embodiment and Embodiment 1 is that a homogeneous motor 800 is arranged on the evaporating hydration tank 200, and during the preparation and film-forming process of liposomes, the material is agitated by scraping the wall of the stirring motor stirring paddle. Under the action of gravity, the material continuously collides with the stirring paddle under the action of gravity, and finally forms a solid mixture. After the hydration solution is added, most of the material is suspended in the liquid. At this time, the homogeneous motor 800 can remove the suspended solid particles Effective pulverization greatly shortens the hydration time.

[0052] In this embodiment, the evaporation and hydration tank 200, the hydration liquid storage tank 100, and the extruder 400 all use jackets for temperature control, and the system temperature can be quickly adjusted by switching the jacket circulating water through the control s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The present application discloses a liposome preparation device, including a hydration liquid storage tank, an evaporative hydration tank, a high-pressure pump, an extruder, and a filter. The evaporative hydration tank is connected to the high-pressure pump through a connecting pipe, the high-pressure pump is connected to the extruder through a connecting pipe, and the extruder is connected to the hydration liquid storage tank through a connecting pipe. The extruder is connected to the filter through a connecting pipe, stirring motors are respectively set on the hydration liquid storage tank and the evaporation hydration tank, and control valves are correspondingly set on each connecting pipe . The process of using this device to prepare liposomes includes four stages: evaporation film formation, hydration, particle size control, and filtration sterilization. The device operates according to the set program under the control of the control system, and finally obtains a controllable particle size. Uniformly distributed liposome solution. The large-scale and automatic preparation of liposomes is realized, and the liposomes are of high quality.

Description

technical field [0001] The application belongs to the field of medicine or cosmetic preparation, and relates to a liposome preparation device and a preparation method, in particular to an automatic liposome preparation device based on a passive drug loading method and a method for preparing liposomes using the device. Background technique [0002] Liposomes are made of phospholipids and additives as the skeleton membrane material, and are closed vesicles with a bilayer structure. The common phospholipid molecular structure has two longer hydrophobic hydrocarbon chains and one hydrophilic group. When an appropriate amount of phospholipid is added to water or a buffer solution, the phospholipid molecules are arranged in an orientation, and its hydrophilic groups face the water phase on both sides, and the hydrophobic hydrocarbon chains are relatively associated with each other to form a bilayer to form a liposome. [0003] Liposomes are divided into unilamellar liposomes and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/14A61K8/67A61K9/127A61K47/28A61K31/337A61Q19/00
Inventor 胡权
Owner 胡权