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Application of cholic acid as active ingredient in preparation of medicine for treatment of echinococcosis granulosa

A technology for echinococcosis and echinococcosis, applied in the field of medicinal chemistry, can solve problems such as liver injury, cell damage, and variable pharmaceutical effects

Inactive Publication Date: 2015-11-04
姜玉峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, on the whole, extravasation of the scoliosis and improper handling of the scoliosis during surgery are insurmountable defects in the surgical treatment of cystic echinococcosis.
[0003] For the problems referred to above, this area attempts to adopt high-concentration acidic (HCl) and alkaline solution (KOH) in vitro, and the local chemotherapeutic drug commonly used in clinic has 20% hypertonic saline, but has certain destructive effect to surrounding normal liver tissue; Studies in the field have also found that bile can inhibit the development of hydatid cysts, but bile has complex components, multiple targets, and variable pharmaceutical effects. For example, the retention of bile and bile acids in the liver and blood will produce a variety of toxic effects, including cytotoxicity. The effects of acute and chronic toxicity can cause liver damage and systemic multi-system and multi-organ damage, and eventually lead to liver cirrhosis, liver failure and death; studies have also found that bile acids can cause damage to pancreatic acinar cells, etc.

Method used

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  • Application of cholic acid as active ingredient in preparation of medicine for treatment of echinococcosis granulosa
  • Application of cholic acid as active ingredient in preparation of medicine for treatment of echinococcosis granulosa
  • Application of cholic acid as active ingredient in preparation of medicine for treatment of echinococcosis granulosa

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Embodiment Construction

[0022] In order to illustrate the application effect of cholic acid (CA), the applicant conducted an in vitro experiment to illustrate the killing effect of cholic acid on the protoscole of Echinococcus granulosus.

[0023] Experiment 1: The effect of CA on the protoscole of Echinococcus granulosus in vitro

[0024] Take fresh liver of sheep naturally infected with Echinococcus granulosus, clean the surface of sheep liver, disinfect the surface with 75% alcohol, extract the cyst fluid containing protoscoleum under aseptic conditions, and transfer it into a sterile bottle. The protoscolm was washed with PBS (PH=7.2) for 3 times until clarified, and the dye rejection test was performed with 0.1% eosin dye solution, and the dye rejection was over 98%. The protoscole was observed with the naked eye as fine white sand-like uniform particles, and the protoscole with good activity had a fast sedimentation rate, while the protoscole with poor activity or death had a relatively slow se...

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Abstract

The present invention discloses application of cholic acid as an active ingredient in preparation of a medicine for treatment of echinococcosis granulosa, and the cholic acid is used to kill echinococcosis granulosa pathogen-echinococcosis granulosa tapeworm, has significant echinococcosis granulosa protoscolex inhibition and killing effect, and can achieve the treatment of echinococcosis granulosa.

Description

technical field [0001] The invention relates to the pharmaceutical application of cholic acid and belongs to the field of medicinal chemistry. Background technique [0002] Echinococcus granulosus (Echinococcus granulosus, Eg), also known as cystic echinococcosis (CE), is caused by the middle-stage larvae of Echinococcus granulosus (Eg) Zoonotic parasitic diseases for health and livestock development. The disease is distributed globally and is mainly prevalent in Xinjiang, Qinghai, Inner Mongolia, Tibet and other provinces with developed animal husbandry in my country. Cystic echinococcosis primarily affects the liver, but can also develop in the lungs. At present, the treatment for this disease is mainly a surgical method, that is, complete resection of the outer and outer capsules of the hepatic hydatid adventitia. Although the complete excision of the outer and outer capsules of the hepatic hydatid cysts adopted in recent years can greatly reduce the recurrence rate of...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61P33/10
Inventor 姜玉峰吕海龙史红娟
Owner 姜玉峰
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