An online micro-reaction device
A technology of micro-reaction devices and micro-reactors, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of highly complex components, time-consuming and labor-consuming, cumbersome operations, etc., and achieve controllable reactions, good versatility, and easy maintenance. simple effect
Active Publication Date: 2018-03-09
李绍平
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[0002] As one of the most powerful tools in analytical chemistry, liquid chromatography has been widely used in the fields of pharmaceutical analysis, food safety and life sciences, which can effectively achieve the separation and analysis of target components; however, a single liquid There are certain limitations in the phase chromatography system, especially in the field of medicinal chemistry. Due to the highly complex components of natural products, traditional Chinese medicine products and other biological samples, which often contain hundreds of compounds, they must be separated and identified in complex mixture systems The production of biologically active ingredients cannot be solved by a single liquid chromatography system, which is also an important problem facing modern medicinal chemistry.
At present, most of the conventional bioactivity identification methods of components use liquid chromatography and similar separation systems to separate the components in the sample, and then screen each component one by one through specific biochemical reactions, but this method is time-consuming and labor-intensive. cumbersome and inefficient
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[0024] The specific implementation manners of the present invention will be further described in detail below in conjunction with the accompanying drawings.
[0025] Such as Figure 1-5 As shown, an online micro-reaction device 100 is used in combination with a liquid chromatography system 200, including a micro-mixer 20 and an adjustable micro-reactor 30 communicated with the micro-mixer 20; the adjustable micro-reactor 30 can also be increased as required The micro-splitter 10 is used to accurately control the flow rate of the effluent liquid in the liquid chromatography system 200; wherein, the micro-splitter 10 is arranged between the liquid chromatography system 200 and the micro-mixer 20, such as figure 1 As shown, the effluent from the liquid chromatography system 200 passes through the micro-splitter 10 , the micro-mixer 20 and the micro-reactor 30 in sequence, and then flows into the detector for detection.
[0026] Specifically, such as image 3 As shown, the micro...
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The present invention relates to the technical field of analytical chemistry instruments and equipment, in particular to an online micro-reaction device used in conjunction with a liquid chromatography system, comprising a micro-mixer and an adjustable micro-reactor connected to the micro-mixer; wherein the The micro mixer comprises a mixing chamber, at least two first liquid inlets arranged at the lower end of the mixing chamber and a first liquid outlet arranged at the upper end of the mixing chamber, wherein one of the first liquid inlets is connected to the The liquid chromatography system is connected; the microreactor includes a reaction chamber, a second liquid inlet arranged at the lower end of the reaction chamber and a plurality of second liquid outlets arranged at the side of the reaction chamber, the first The second liquid inlet is connected with the first liquid outlet, and the second liquid outlet is used for connecting with the detector. The invention has the advantages of small size, convenient installation, and simple maintenance; and has good versatility, is compatible with all liquid chromatography systems, is connected with different detectors, and has controllable reactions.
Description
technical field [0001] The invention relates to the technical field of analytical chemistry instruments and equipment, in particular to an online micro-reaction device used in conjunction with a liquid chromatography system. Background technique [0002] As one of the most powerful tools in analytical chemistry, liquid chromatography has been widely used in the fields of pharmaceutical analysis, food safety and life sciences, which can effectively achieve the separation and analysis of target components; however, a single liquid There are certain limitations in the phase chromatography system, especially in the field of medicinal chemistry. Due to the highly complex components of natural products, traditional Chinese medicine products and other biological samples, which often contain hundreds of compounds, they must be separated and identified in complex mixture systems The production of biologically active ingredients cannot be solved by a single liquid chromatography syste...
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IPC IPC(8): G01N30/06G01N1/28
Inventor 李绍平赵静
Owner 李绍平