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Improved synthesis method for dencichine

A synthesis method and technology of Panax notoginseng, applied in the field of medicine, can solve the problems of low extraction rate of Panax notoginseng, small profit margin and the like

Inactive Publication Date: 2015-11-18
西安岳达生物科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the extraction rate of natural notoginseng is low, and the profit margin is small

Method used

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  • Improved synthesis method for dencichine
  • Improved synthesis method for dencichine
  • Improved synthesis method for dencichine

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Experimental program
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Embodiment

[0018] The synthesis method of notoginseng is obtained: take 6.01g of sodium hydroxide, dissolve it in 100mL of water, cool down to 0 degrees, add 20g of L-asparagine, stir for 30 minutes, add 200mL of acetone and 31.4g of K 2 CO 3 , keep the temperature not higher than 5 degrees, add 39.6g di-tert-butyl dicarbonate dropwise, rise to room temperature and react for 24 hours, add 300mL water to dissolve, adjust the pH to 6-7 with 0.5mol / L HCl, extract (dichloro Methane:methanol, 4:1, 200mL×5), retain the aqueous phase, adjust the pH of the aqueous phase to 3-4 with 0.5mol / L HCl, extract (dichloromethane:methanol, 4:1, 200mL×10), no After drying with sodium sulfate and spin-drying, 33g of Boc-L-asparagine was obtained. 33g of Boc-L-asparagine was dissolved in 96mL of ethyl acetate, 96mL of acetonitrile, 1.0mL of saturated citric acid and 48mL of water. After cooling to 0°C, Add 33.3g of diacetoxyiodobenzene in batches, rise to room temperature and react for 4 hours, a solid prec...

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Abstract

The invention discloses an improved synthesis method for dencichine, and belongs to the fields of medicine and chemical engineering. Dencichine is a white solid, and can be used for hemostasis by shortening blood coagulation time and thrombinogen time, thereby being important medicine; while, natural dencichine is low in extraction rate, and low in profit margin. The improved synthesis method is an efficient way to obtain dencichine according to a chemosynthesis method, and is low in cost, suitable for industrial production, and low in reaction cost, thereby providing an important reference for industrialization.

Description

technical field [0001] The invention relates to an improvement of a synthetic method of notoginseng, which belongs to the technical fields of medicine and chemical industry. Background technique [0002] Panax notoginseng is a white solid, panax notoginseng can play a hemostatic effect by shortening coagulation time, prothrombin time, etc., and is an important medicinal body. But the extraction rate of natural notoginseng is low, and the profit margin is small. The method is an effective way to obtain notoginseng through chemical synthesis, and has low cost and can be produced industrially. Contents of the invention [0003] In this patent, through the exploration and optimization of the synthesis process of notoginseng, the synthesis process of notoginseng is finally obtained. Panax notoginseng is an important medicinal body. [0004] The synthetic method of notoginseng of the present invention is to adopt L-asparagine as raw material, react with di-tert-butyl dicarbon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/56C07C231/14
Inventor 张天毛羽
Owner 西安岳达生物科技股份有限公司
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