Preparation method of water-based ceramide

A technology of ceramide and preparation method, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of failing to reach the nanometer level, not having the ability to penetrate the skin, and the product effect is not obvious, and achieve repair Damaged skin barrier, extended use, enhanced effect of intended use

Inactive Publication Date: 2015-11-25
珠海雅莎生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are various brands of products in the cosmetics market, such as essence, cream, lip balm gel and concealer cosmetics, but other methods in the domestic market prepare water-based ceramides, such as adding biosurfactants to make water-based ceramides, but It fails to reach the nanometer level, does not have good skin penetration ability, and the product effect is not obvious
At present, there is no similar technology in China

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of Ceramide Soothing Moisturizing Water

[0025] 1. Measure 500ml of purified water into a 1000ml beaker, add 100g of glycerin, stir evenly to make a latent solvent.

[0026] 2. Add 20g of surfactant potassium polysorbate 20 and 40g of potassium polysorbate 80 as dispersant, and stir well.

[0027] 3. Add 10g of polyvinylpyrrolidone K30 as a protective agent, and use its macromolecular steric hindrance effect to prevent crystallization of ceramide particles and increase the stability of ceramide in water-based liquids.

[0028] 4. Take 50g of ceramide (the content can be increased according to the concentration of the product), add 50g of glycerin, stir well, slowly add into the above solution under stirring, and stir for 10 minutes.

[0029] 5. Add water to 1000ml.

[0030] 6. Take 2.5ml of the water-based ceramide prepared in step 5, add it to a 50ml volumetric flask, add purified water to make up to 50ml, add it to a bottle with a spray pump h...

Embodiment 2

[0031] Example 2 Clinical curative effect of ceramide soothing moisturizing water

[0032] From June 2014 to January 2015, internal control clinical efficacy observations were carried out on the ceramide soothing moisturizing water of the present invention. A total of 64 patients in this group were outpatients. Among them, there were 40 females and 24 males, aged 17-35 years, with an average of 24.6 years, and the course of disease was 3 months to 6 years, with an average of 2.6 years; the primary diseases included cosmetic dermatitis, allergic dermatitis, steroid-dependent dermatitis, dermatitis eczema, acne dermatitis etc.

[0033] 1. Clinical manifestations and symptoms: burning itching, pain, wrinkled skin, desquamation or tightness, erythema, telangiectasia or flushing and edema, papules or pustules or acne, pigmentation or epidermal atrophy.

[0034] 2. Therapeutic method: spray with the ceramide soothing moisturizing water prepared by the present invention, 3-5 times ...

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PUM

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Abstract

The invention discloses a formula of water-based ceramide and a preparation method. Each 1000ml of the water-based ceramide solution contains 1-50 g of ceramide, 10-150 g of glycerinum, 10-20 g of polypotassium sorbate 20, 15-40 g of polypotassium sorbate 80, and 1-10 g of polyvinylpyrrolidone K30. According to the preparation method, the nanometer high-tech dispersion technology is adopted for carrying out high dispersion on the ceramide in water base, so that the particle size of ceramide is smaller than 20nm, then the ceramide can easily penetrate through the aged cuticle of the skin, therefore, deep repairing is carried out on the cuticle cells, and the perfect skin barrier is constructed.

Description

technical field [0001] The invention relates to a configuration method of water-based ceramide, in particular to the use of high-tech dispersion technology to increase the absorbability of ceramide by the skin, and belongs to the fields of medical cosmetology, medicine, cosmetics and other industries. Background technique [0002] Ceramides, also known as sphingolipids, are structural units shared by (nerve) sphingolipids. They are a kind of lipids present in the skin and play an important role in the formation of the epidermal stratum corneum. Fatty acid has an acid amide bond structure on the amino group of sphingosine. If it is combined with sugar, it will become glycosphingolipid; if it is combined with phosphorylcholine, it will become (nerve) sphingomyelin. Ceramide is an intermediate metabolite of sphingolipids, especially in biosynthesis. Only a small amount exists outside of platelets. Patients with Fabry's disease, one of the hereditary lipidosis, accumulate a la...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/68A61K8/84A61K8/06A61K8/04A61K31/164A61K9/107A61K9/06A61Q19/00A61P17/00A61P17/04A61P17/10
Inventor 钱捷豪陆贵平谢伟王刚平
Owner 珠海雅莎生物科技股份有限公司
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