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Preparation method of fructus forsythiae antidotal tablet

A technology for Yinqiaojiedu tablet and prescription is applied in the field of Yinqiaojiedu tablet and its preparation, which can solve the problems of influence of drug efficacy, reduce the yield of effective components of drugs and the like, and achieve the effect of good drug efficacy

Inactive Publication Date: 2015-11-25
韩志强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method follows the ancient method of decocting and merging medicinal liquid twice as much as possible, in the modern production process, the simple method also greatly reduces the yield of active ingredients of the drug, which affects the efficacy of the drug

Method used

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  • Preparation method of fructus forsythiae antidotal tablet
  • Preparation method of fructus forsythiae antidotal tablet
  • Preparation method of fructus forsythiae antidotal tablet

Examples

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Effect test

Embodiment 1

[0028] Example 1. Yinqiao Jiedu Tablets

[0029] Prescription: Honeysuckle 200g mint 120g light tempeh 100g burdock (fried) 120g bellflower 120g light bamboo leaves 80g licorice 100g

[0030] Excipients: magnesium stearate and beta-dextrin

[0031] Made: 500 tablets 1.02g

[0032] Preparation:

[0033] (1) Extraction of honeysuckle forsythia and light tempeh extract:

[0034] Soak the prescription amount of honeysuckle forsythia and light fermented soya bean respectively with 2 times the volume of 50% ethanol and stir thoroughly at a stirring speed of 180rpm / min, the first time for 2 hours, the second time for 2 hours, filter, and combine the two extracts ,

[0035] (2) Supercritical CO2 extraction of volatile oil

[0036] Grind mint and Nepeta in the prescribed amount and pass through a 20-mesh sieve, mix with (1) honeysuckle and Rhizoma chinensis, and put them into supercritical CO 2 In the extraction kettle of the extractor, and adding 100l volume concentration in the...

Embodiment 2

[0047] (1) Extraction of honeysuckle forsythia and light tempeh extract:

[0048] Soak the prescription amount of honeysuckle forsythia and light fermented soya bean respectively with 2 times the volume of 50% ethanol and stir thoroughly at a stirring speed of 180rpm / min, the first time for 2 hours, the second time for 2 hours, filter, and combine the two extracts ,

[0049] (2) Supercritical CO2 extraction of volatile oil

[0050] Grind mint and Nepeta in the prescribed amount and pass through a 20-mesh sieve, mix with (1) honeysuckle and Rhizoma chinensis, and put them into supercritical CO 2 In the extraction kettle of the extractor, and adding 100l volume concentration in the extraction kettle is 95% ethanol as entrainer;

[0051] Heat the extraction kettle, separation kettle, separation kettle Ⅰ, and separation kettle Ⅱ. When the extraction temperature is 25°C and the temperature of the separation kettle Ⅰ is 20°C, turn on the CO 2 Cylinder, until the pressure of the e...

Embodiment 3

[0061] Prescription: Honeysuckle 200g mint 120g light tempeh 100g burdock (fried) 120g bellflower 120g light bamboo leaves 80g licorice 100g

[0062] Excipients: magnesium stearate and beta-dextrin

[0063] Made: 500 tablets 1.02g

[0064] Preparation:

[0065] (1) Extraction of honeysuckle forsythia and light tempeh extract:

[0066] Soak the prescription amount of honeysuckle forsythia and light fermented soya bean respectively with 2 times the volume of 50% ethanol and stir thoroughly at a stirring speed of 180rpm / min, the first time for 2 hours, the second time for 2 hours, filter, and combine the two extracts ,

[0067] (2) Supercritical CO2 extraction of volatile oil

[0068] Grind mint and Nepeta in the prescribed amount and pass through a 20-mesh sieve, mix with (1) honeysuckle and Rhizoma chinensis, and put them into supercritical CO 2 In the extraction kettle of the extractor, and adding 100l volume concentration in the extraction kettle is 95% ethanol as entrai...

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Abstract

The invention relates to a fructus forsythiae antidotal tablet and a preparation method of the fructus forsythiae antidotal tablet. The fructus forsythiae antidotal tablet is prepared through the preparation method which comprises the following steps: honeysuckle, fructus forsythia and fermented soybean are soaked with an appropriate volume of 50% ethanol, leachate is extracted, volatile oil in dregs of mint, herba schizonepetae, honeysuckle and fructus forsythia is extracted by a supercritical CO2 extraction method, wherein ethanol is used as a cosolvent, and after refining, the volatile oil is covered with beta-cyclodextrin; and lophatherum gracile, liquorice and great burdock achene are extracted through a continuous dynamic multiple extraction method, and residual dregs and liquor of the volatile oil are extracted; and the leachate and the extraction liquid are merged and concentrated, an auxiliary material is added in the concentrate to prepare a soft material, and platycodon grandiflorum powder and the volatile oil covered with beta-cyclodextrin are mixed in the soft material to prepare the fructus forsythiae antidotal tablet, wherein the weight of each tablet is 1.02 g. In the fructus forsythiae antidotal tablet, the contents of effective components with different solubility properties are all improved, the stability is enhanced, and besides, the exertion of the drug properties of the compatibility of the herbal pairs of monarch drugs is considered to the greatest degree in the preparation process of Chinese patent medicines. The fructus forsythiae antidotal tablet, disclosed by the invention, can exert the effects of expelling wind to resolve the exterior and clearing away heat and toxic materials, relieves corresponding cold symptoms, is low in irritation to stomach and intestine, is low in side effects, and has a good effect.

Description

Technical field: [0001] The present invention relates to Yinqiao Jiedu tablet and its preparation method technical background: [0002] Traditional Chinese medicine believes that wind-heat cold is a symptom caused by feeling the evil of wind-heat, which is more common in summer and autumn. "On the Origin and Symptoms of Various Diseases: Wind-heat Diseases": "For wind-heat patients, the air of wind-heat first enters the lungs from the skin. Qi first hurts the fur and then enters the lungs. Its shape makes people feel wind and chills, eyes are about to fall off, and tears are spit out. It should be treated with Xinliang to relieve the exterior and disperse wind-heat. Prescriptions are Yinqiaosan, Sangjuyin, and Jugendou Decoction , Shangqing San, Juhua San, etc." Among them, Yinqiao San is the main prescription for wind-heat and cold, and its functions and indications are: dispelling wind and relieving the exterior, clearing away heat and detoxifying, symptoms include fever,...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/28A61P11/00
Inventor 韩志强
Owner 韩志强
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