Copper-based human albumin nano-composite with near infrared thermal effect as well as preparation method and application of copper-based human albumin nano-composite

A nanocomposite and blood albumin technology, which is applied in the field of copper-based human serum albumin nanocomposite and its preparation, can solve the problem of weak photothermal heating ability of nanoparticles, limited effect of inhibiting tumors in animals, and low photothermal conversion efficiency, etc. problems, to achieve good tumor targeting, good light stability, and good blood compatibility
CN105106958AActive Publication Date: 2015-12-02SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2015-12-02

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Abstract

The invention discloses a copper-based human albumin nano-composite with a near infrared thermal effect as well as a preparation method and an application of the copper-based human albumin nano-composite. Growth of an inorganic copper-based nano-composite is induced by controlling the protein concentration, the concentration of a copper salt, the pH of a reaction solution, the reaction time and the reaction temperature; and the copper-based nano structure of a copper sulphate or copper selenide-coated nano composite employing human albumin as a skeleton is synthesized. The copper-based human albumin nano-composite with the near infrared thermal effect has the characteristics of good dispersity, good light stability, high photothermal conversion efficiency, good in-vivo tumor targeting property and the like, and can be applied to photothermal therapy; and efficient heat removal of tumors is realized.
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Description

technical field

[0001] The invention relates to a copper-based human serum albumin nanocomposite and its preparation method and application, in particular to a copper-based human serum albumin nanocomposite with near-infrared photothermal effect and its preparation method and application. Background technique

[0002] Photothermal therapy (PTT) is a minimally invasive tumor treatment technology that has developed rapidly in recent years. Under the excitation of incident light, the light-absorbing agent targeted to the tumor can use its photothermal conversion effect to generate heat, which can increase the local temperature of the tumor and reach a certain temperature (above 42°C), thereby achieving the effect of killing tumor cells. Through the tumor-targeted delivery of photothermal conversion substances and the selective irradiation of tumor sites, the systemic toxicity of the whole body is greatly reduced. Therefore, photothermal therapy is considered to be a promising t...

Claims

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