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Brain functional network activity level measurement method

A functional network and measurement method technology, applied in the field of brain functional network, can solve the problems of very little research on the measurement of node activity and few researches on brain functional network nodes.

Inactive Publication Date: 2015-12-09
CHANGZHOU UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

Most of the research in this area is limited to the detection of certain activated brain regions or the detection of general functional connectivity between brain regions. There are not many studies on brain functional network nodes in domestic and foreign patent literature, especially research on the measurement of node activity. very few

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Embodiment Construction

[0028] The present invention will be further described below in conjunction with the drawings and specific embodiments.

[0029] Such as figure 1 As shown, a method for measuring the activity level of a brain function network, a specific embodiment includes the following steps:

[0030] (1) Conduct two sets of experiments:

[0031] Experiment 1: Perform resting functional magnetic resonance scanning on 30 normal subjects (15 males and 15 females, aged 20-40 years);

[0032] Experiment 2: Twenty patients (10 males, 10 females) with cerebral infarction were taken as specific subjects to undergo resting functional magnetic resonance scanning.

[0033] The functional magnetic resonance images of the two groups of subjects were converted from DICOM format to NIFTI format, and the converted images were preprocessed, including format conversion, time correction, head movement correction, registration, spatial standardization, smoothing, and Operations such as linear drift and filtering. In t...

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Abstract

The invention discloses a brain functional network activity level measurement method. The method includes the steps: respectively carrying out functional magnetic resonance imaging on a normal subject and a specific subject, and subjecting brain functional magnetic resonance images acquired under identical conditions to preprocessing operations; using a standard partition template to divide the brain functional magnetic resonance images into a plurality of brain areas, defining each brain area as a node and defining connection between each two brain areas as a side for connection of the corresponding nodes to enable a whole brain to form a functional network with a plurality of nodes and the connection sides among the nodes; according to a level of each node and a maximum number of the connection sides among each node and the surrounding nodes, respectively calculating a corresponding node activity level of each brain area of the specific subject and an average node activity level of the whole brain functional network of the normal subject, comparing and taking the brain areas high in activity level as active areas. According to the brain functional network activity level measurement method, connection closeness of the brain areas is reflected by the node activity levels of the brain functional network, and the activity level of each single area can be observed specifically. The brain functional network activity level measurement method has a certain application value in the fields of brain functional regulation, cognitive function research, mental disease diagnosis and treatment and the like.

Description

Technical field [0001] The present invention belongs to the research of brain function network, and specifically involves abstracting each functional partition of the brain into nodes, and abstracting the connections between all nodes into a brain function network, and then measuring the activity of the partition nodes. Background technique [0002] The brain is a complex and very important organ, which controls the coordination of the entire body. At present, people do not know much about the brain. With the advancement of science and technology, especially the application of functional magnetic resonance, people have a better understanding of the mysteries inside the brain. For example, in the case of resting state, activity, stimulation or disease, the activity of the corresponding brain area can be observed through the change of blood oxygen content. In the early years, the research on brain science may be limited to medicine, but in recent years, more and more other discipl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055
Inventor 焦竹青马凯邹凌项艰波马正华
Owner CHANGZHOU UNIV
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