Preparation method of Chimaera phantasma Jordan et Snyder extract and application of Chimaera phantasma Jordan et Snyder extract to preparation of alcoholic liver injury protective drug

Abstract

The invention discloses a preparation method of a Chimaera phantasma Jordan et Snyder extract and an application of the Chimaera phantasma Jordan et Snyder extract to preparation of an alcoholic liver injury protective drug. The preparation method is characterized in that fresh Chimaera phantasma Jordan et Snyder is cooked, fish meat is removed, cartilage is washed with clean water and minced, an NaOH solution is added in the mass ratio of the cartilage to the solution being 1: (1-1.5), the mixture is stirred and extracted for 4 h, then pH is regulated to be 6-7 with HCl, filtration is performed, NaOH is added to a filtrate to regulate the pH to be 8.5-9.0, and compound protease is added in the mass ratio of the solution to the compound protease being 1,000:1 for hydrolysis for 4 h; a hydrolysate is heated for 30 min at 80 DEG C, HCl is added to regulate the pH to be 2, the mixture is left to stand, an upper solution is subjected to pumping filtration by the aid of kieselguhr, NaOH is added to regulate the pH to be 10.5, filtration is performed after decoloring with hydrogen peroxide, HCl is added to a filtrate to regulate the pH to be 7, the filtrate is subjected to decompression concentration to a small volume, and the Chimaera phantasma Jordan et Snyder extract is obtained after precipitation and drying. The Chimaera phantasma Jordan et Snyder extract enhances the capability of a body for removing peroxidatic reaction products by enhancing the activity of antioxidant enzymes and can be used as an alcoholic liver injury protective agent.

Description

technical field [0001] The present invention relates to a preparation method of black line chimaera extract and its application in the preparation of alcoholic liver damage protection medicine. Background technique [0002] At present, alcoholism and addiction have become a global problem. Long-term heavy drinking can cause damage to multiple organs throughout the body, especially to the liver. Chronic alcoholism can lead to symptoms such as alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis, fibrosis, and in severe cases, canceration. At present, for the treatment of alcoholic liver poisoning, many methods include amino acid and glucose infusion, multivitamins, maintenance of water, electrolyte and acid-base balance, etc. In recent years, many researchers have tried to find a method that can effectively prevent and protect the liver from Medicines that lessen the damaging effects of alcohol on the liver. [0003] Black-lined chimaera (Chimaeraphantasma Jordan...

AI Technical Summary

Problems solved by technology

Distributed in the western Pacific Ocean, China is produced in the South China Sea, the East China Sea and the Yellow Sea. The internal skeleton is all cartilage. The preparation method of the black line chimaera extract and its application in the preparation of alcoholic liver injury protection drugs have not been reported so far.